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ChemicalBook >> CAS DataBase List >> Entrectinib

Entrectinib

Entrectinib price.
  • $10 - $1397
  • Product name: Entrectinib
  • CAS: 1108743-60-7
  • MF: C31H34F2N6O2
  • MW: 560.64
  • EINECS:
  • MDL Number:MFCD28129099
  • Synonyms:Entrectinib;Entrectinib(NMS-E628);Entrectinib,NMS-E628,RXDX-101;entrecitinib;Entrectinib(RXDX-101);NMS-E628;CS-1589;NMS E628; RXDX-101;NMSE628; RXDX 101;NMS-E628; RXDX101
Price50 Properties Safety Information Description
50 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
Package
  • 10mg
  • 10mM(1mLinDMSO)
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 10mM*1mLinDMSO(Solution)
  • 10mM*1mLinDMSO
  • 25.00mg
  • 50.00mg
  • 100.00mg
  • 250mg
  • 1mg
  • 10mM(in1mLDMSO)
  • 5mg
  • 25mg
  • 50mg
  • 100mg
  • 500mg
  • 1G
  • 10mM(in 1mL DMSO)
  • Manufactureraablocks
  • Product numberAA0039QC
  • Product descriptionN-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide ≥98%
  • Packaging1mg
  • Price$10
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039QC
  • Product descriptionN-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide ≥98%
  • Packaging5mg
  • Price$16
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039QC
  • Product descriptionN-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide ≥98%
  • Packaging25mg
  • Price$60
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039QC
  • Product descriptionN-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide 98%
  • Packaging50mg
  • Price$105
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039QC
  • Product descriptionN-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide 98%
  • Packaging100mg
  • Price$150
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039QC
  • Product descriptionN-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide ≥98%
  • Packaging500mg
  • Price$709
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberK13380
  • Product descriptionEntrectinib 98%
  • Packaging1G
  • Price$595
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberK13380
  • Product descriptionEntrectinib 98%
  • Packaging25MG
  • Price$40
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberK13380
  • Product descriptionEntrectinib 98%
  • Packaging100MG
  • Price$150
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number2923DC
  • Product descriptionEntrectinib
  • Packaging5mg
  • Price$232
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5859
  • Product descriptionEntrectinib
  • Packaging10mM(in1mLDMSO)
  • Price$209
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5859
  • Product descriptionEntrectinib
  • Packaging25mg
  • Price$293
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5859
  • Product descriptionEntrectinib
  • Packaging5mg
  • Price$71
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5859
  • Product descriptionEntrectinib
  • Packaging10mM(in 1mL DMSO)
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5859
  • Product descriptionEntrectinib
  • Packaging100mg
  • Price$663
  • Updated2026-05-06
  • Buy
  • ManufacturerArctom
  • Product numberSLK-S7998
  • Product descriptionEntrectinib (RXDX-101) 99.93%
  • Packaging1g
  • Price$1397
  • Updated2026-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA0039QC N-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide ≥98% 1mg $10 2026-05-28 Buy
aablocks AA0039QC N-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide ≥98% 5mg $16 2026-05-28 Buy
aablocks AA0039QC N-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide ≥98% 25mg $60 2026-05-28 Buy
aablocks AA0039QC N-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide 98% 50mg $105 2026-05-28 Buy
aablocks AA0039QC N-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide 98% 100mg $150 2026-05-28 Buy
aablocks AA0039QC N-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide ≥98% 500mg $709 2026-05-28 Buy
ACHEMBLOCK K13380 Entrectinib 98% 1G $595 2026-05-27 Buy
ACHEMBLOCK K13380 Entrectinib 98% 25MG $40 2026-05-27 Buy
ACHEMBLOCK K13380 Entrectinib 98% 100MG $150 2026-05-27 Buy
AK Scientific 2923DC Entrectinib 5mg $232 2021-12-16 Buy
ApexBio Technology B5859 Entrectinib 10mM(in1mLDMSO) $209 2026-05-06 Buy
ApexBio Technology B5859 Entrectinib 25mg $293 2026-05-06 Buy
ApexBio Technology B5859 Entrectinib 5mg $71 2026-05-06 Buy
ApexBio Technology B5859 Entrectinib 10mM(in 1mL DMSO) $130 2021-12-16 Buy
ApexBio Technology B5859 Entrectinib 100mg $663 2026-05-06 Buy
Arctom SLK-S7998 Entrectinib (RXDX-101) 99.93% 1g $1397 2026-05-26 Buy
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Properties

Boiling point :717.5±60.0 °C(Predicted)
Density :1.340±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥28.05 mg/mL in DMSO; insoluble in H2O; ≥9.82 mg/mL in EtOH with ultrasonic
form :solid
pka :12.01±0.43(Predicted)
color :Off-white to light yellow
InChIKey :HAYYBYPASCDWEQ-UHFFFAOYSA-N
SMILES :C(NC1C2=C(NN=1)C=CC(CC1=CC(F)=CC(F)=C1)=C2)(=O)C1=CC=C(N2CCN(C)CC2)C=C1NC1CCOCC1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Entrectinib is an inhibitor of TrkA (IC50 = 1.7 nM), TrkB (IC50 = 0.1 nM), and TrkC (IC50 = 0.1 nM), as well as C-ros oncogene 1 (ROS1; IC50 = 0.2 nM) and anaplastic lymphoma kinase (ALK; IC50 = 1.6 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with L1196M or C1156Y resistance mutations, and inhibits ALK‐dependent signaling. It has been shown to inhibit the growth of a non-small cell lung cancer cell line bearing an EML4-ALK rearrangement. In mice bearing various Trk, ROS1, or ALK-driven xenografts, entrectinib has been shown to induce tumor regression.

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Suppliers and manufacturers

Chengdu Celes Technology Co., Ltd Shanghai Biobond Pharmaceutical Co.,Ltd. JINAN RUIFENG PHARMACEUTICAL TECHNOLOGY CO.,LTD Changzhou Borl Biotechnology Co.,LTD Shanghai Boyle Chemical Co., Ltd. Chembest Research Laboratories Limited WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. Dalian Meilun Biotech Co., Ltd. Shanghai Hope Chem Co., Ltd.， Haoyuan Chemexpress Co., Ltd.