KU57788(NU7441)
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- $26 - $2541.5
- Product name: KU57788(NU7441)
- CAS: 503468-95-9
- MF: C25H19NO3S
- MW: 413.49
- EINECS:-0
- MDL Number:MFCD11983069
- Synonyms:KU57788(NU7441);NU 7441;8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one;8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one;NU7441 (KU-57788);KU 57788; NU-7441;KU 57788;NU-7441 (KU-57788);4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-
46 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Tocris
- TRC
Package
- 5mg
- 10mM*1mLinDMSO
- 1unit
- 10mg
- 1MG
- 2mg
- 10
- 50
- 10mM(in1mLDMSO)
- 25mg
- 50MG
- 50.00g
- 100.00g
- 250.00g
- 100mg
- 250mg
- EvaluationSample
- 10mM(in 1mL DMSO)
- 1g
- ManufacturerAK Scientific
- Product numberSYN1096
- Product descriptionKU57788
- Packaging10mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000637
- Product descriptionNU 7441 95.00%
- Packaging1MG
- Price$135.45
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000637
- Product descriptionNU 7441 95.00%
- Packaging50MG
- Price$981.75
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000637
- Product descriptionNU 7441 95.00%
- Packaging10MG
- Price$693
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8315
- Product descriptionNU7441 (KU-57788)
- Packaging25mg
- Price$165
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8315
- Product descriptionNU7441(KU-57788)
- Packaging10mM(in 1mL DMSO)
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8315
- Product descriptionNU7441(KU-57788)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8315
- Product descriptionNU7441 (KU-57788)
- PackagingEvaluationSample
- Price$30
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8315
- Product descriptionNU7441(KU-57788)
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8315
- Product descriptionNU7441 (KU-57788)
- Packaging5mg
- Price$55
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8315
- Product descriptionNU7441 (KU-57788)
- Packaging10mM(in1mLDMSO)
- Price$61
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberCFN60173
- Product descriptionNU7441(KU-57788) ≥98%
- Packaging10mg
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number6614
- Product descriptionNU7441 98%
- Packaging5mg
- Price$50
- Updated2026-05-22
- Buy
- ManufacturerAvaChem
- Product number6614
- Product descriptionNU7441 98%
- Packaging25mg
- Price$135
- Updated2026-05-22
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1463
- Product descriptionNU 7441
- Packaging5mg
- Price$77
- Updated2026-05-19
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1463
- Product descriptionNU7441-KU47788 99%
- Packaging2mg
- Price$44
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN1096 | KU57788 | 10mg | $130 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000637 | NU 7441 95.00% | 1MG | $135.45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000637 | NU 7441 95.00% | 50MG | $981.75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000637 | NU 7441 95.00% | 10MG | $693 | 2021-12-16 | Buy |
| ApexBio Technology | A8315 | NU7441 (KU-57788) | 25mg | $165 | 2026-05-06 | Buy |
| ApexBio Technology | A8315 | NU7441(KU-57788) | 10mM(in 1mL DMSO) | $95 | 2021-12-16 | Buy |
| ApexBio Technology | A8315 | NU7441(KU-57788) | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A8315 | NU7441 (KU-57788) | EvaluationSample | $30 | 2026-05-06 | Buy |
| ApexBio Technology | A8315 | NU7441(KU-57788) | 5mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A8315 | NU7441 (KU-57788) | 5mg | $55 | 2026-05-06 | Buy |
| ApexBio Technology | A8315 | NU7441 (KU-57788) | 10mM(in1mLDMSO) | $61 | 2026-05-06 | Buy |
| Arctom | CFN60173 | NU7441(KU-57788) ≥98% | 10mg | $208 | 2021-12-16 | Buy |
| AvaChem | 6614 | NU7441 98% | 5mg | $50 | 2026-05-22 | Buy |
| AvaChem | 6614 | NU7441 98% | 25mg | $135 | 2026-05-22 | Buy |
| Axon Medchem | Axon1463 | NU 7441 | 5mg | $77 | 2026-05-19 | Buy |
| Axon Medchem | Axon1463 | NU7441-KU47788 99% | 2mg | $44 | 2021-12-16 | Buy |
Properties
Melting point :220-221 °C
Boiling point :646.9±55.0 °C(Predicted)
Density :1.376±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :Soluble in DMSO (up to 10 mg/ml with warming).
form :solid
pka :0.51±0.20(Predicted)
color :Off-white to beige
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI :1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2
InChIKey :JAMULYFATHSZJM-UHFFFAOYSA-N
SMILES :[s]1c2c(c6c1cccc6)cccc2c3c4[o]c(c[c](c4ccc3)=O)N5CCOCC5
Boiling point :646.9±55.0 °C(Predicted)
Density :1.376±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :Soluble in DMSO (up to 10 mg/ml with warming).
form :solid
pka :0.51±0.20(Predicted)
color :Off-white to beige
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI :1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2
InChIKey :JAMULYFATHSZJM-UHFFFAOYSA-N
SMILES :[s]1c2c(c6c1cccc6)cccc2c3c4[o]c(c[c](c4ccc3)=O)N5CCOCC5
Safety Information
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Description
DNA-dependent protein kinase (DNA-PK) catalyzes nonhomologous end-joining, which is required to repair lethal DNA double-strand breaks. Because cells that are defective in DNA double-strand break repair are highly sensitive to ionizing radiation and topoisomerase II poisons, modulating DNA-PK is one strategy to defer cancer cell resistance to radiation or chemotherapeutic treatments. NU 7441 is a selective DNA-PK inhibitor with an IC50 value of 14 nM. It inhibits other members of the PI3K-related kinase family, including mTOR, PI3K, ataxia telangiectasia mutated (ATM), and ataxia telangiectasia and Rad3 related (ATR) with IC50 values of 1.7, 5, >100, and >100 μM, respectively. NU 7441 has been shown to increase the cytotoxicity of ionizing radiation and etoposide in human colon cancer cell lines in vitro and to potentiate the effects of etoposide in mice bearing human colon cancer xenograft tumors in vivo.More related product prices
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