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ChemicalBook >> CAS DataBase List >> LY 2157299

LY 2157299

$13 - $2822
Product name: LY 2157299
CAS: 700874-72-2
MF: C22H19N5O
MW: 369.42
EINECS:-0
MDL Number:MFCD12923319
Synonyms:LY-2157299;LY 2157299;GALUNISERTIB;LY 2157299;4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide;6-QuinolinecarboxaMide, 4-[5,6-dihydro-2-(6-Methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-;4-[2-(6-Methyl-2-pyridinyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxaMideorLY2157299;Galunisertib,LY2157299;4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide;4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide LY 2157299

Price134 Properties Safety Information Description

134 prices

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Brand

aablocks
ACHEMBLOCK
AK Scientific
Ambeed
American Custom Chemicals Corporation
ApexBio Technology
Apolloscientific
Arctom
AvaChem
Axon Medchem
Biorbyt Ltd
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Labseeker
Matrix Scientific
Medical Isotopes, Inc.
Sigma-Aldrich
TCI Chemical
Tocris
TRC
Usbiological

Package

1mg
5
10mM(1mLinDMSO)
1unit
2mg
5mg
10mg
0.025g
25mg
0.05g
0.1g
100.00mg
50mg
25
250.00mg
250mg
500mg
1.00g
1g
5G
10mM(in1mLDMSO)
100mg
200mg
EvaluationSample
0.25g
0.5g
10mM(in 1mL DMSO)

Manufactureraablocks
Product numberAA0033PR
Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%
Packaging100mg
Price$52
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0033PR
Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%
Packaging25mg
Price$28
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0033PR
Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%
Packaging250mg
Price$87
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0033PR
Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%
Packaging10mg
Price$23
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0033PR
Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%
Packaging5mg
Price$19
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0033PR
Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%
Packaging2mg
Price$16
Updated2026-05-28
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Manufactureraablocks
Product numberAA0033PR
Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%
Packaging1mg
Price$13
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0033PR
Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%
Packaging1g
Price$237
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product number10348
Product descriptionLY2157299 98%
Packaging100MG
Price$90
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product number10348
Product descriptionLY2157299 98%
Packaging25MG
Price$35
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product number10348
Product descriptionLY2157299 98%
Packaging1G
Price$300
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product number10348
Product descriptionLY2157299 98%
Packaging5G
Price$1200
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product numberX7574
Product description4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide
Packaging250mg
Price$704
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA150887
Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+%
Packaging1g
Price$614
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA150887
Product descriptionGalunisertib 98%
Packaging1g
Price$300
Updated2026-06-05
Buy

ManufacturerAmbeed
Product numberA150887
Product descriptionGalunisertib 98%
Packaging5g
Price$1286
Updated2026-06-05
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA0033PR	4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%	100mg	$52	2026-05-28	Buy
aablocks	AA0033PR	4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%	25mg	$28	2026-05-28	Buy
aablocks	AA0033PR	4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%	250mg	$87	2026-05-28	Buy
aablocks	AA0033PR	4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%	10mg	$23	2026-05-28	Buy
aablocks	AA0033PR	4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%	5mg	$19	2026-05-28	Buy
aablocks	AA0033PR	4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%	2mg	$16	2026-05-28	Buy
aablocks	AA0033PR	4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%	1mg	$13	2026-05-28	Buy
aablocks	AA0033PR	4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98%	1g	$237	2026-05-28	Buy
ACHEMBLOCK	10348	LY2157299 98%	100MG	$90	2026-05-27	Buy
ACHEMBLOCK	10348	LY2157299 98%	25MG	$35	2026-05-27	Buy
ACHEMBLOCK	10348	LY2157299 98%	1G	$300	2026-05-27	Buy
ACHEMBLOCK	10348	LY2157299 98%	5G	$1200	2026-05-27	Buy
AK Scientific	X7574	4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide	250mg	$704	2021-12-16	Buy
Ambeed	A150887	4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+%	1g	$614	2021-12-16	Buy
Ambeed	A150887	Galunisertib 98%	1g	$300	2026-06-05	Buy
Ambeed	A150887	Galunisertib 98%	5g	$1286	2026-06-05	Buy

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Properties

Melting point :241-242°C
Boiling point :619.0±55.0 °C(Predicted)
Density :1.40
Flash point :328.162℃
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml)
form :solid
pka :15.27±0.30(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI :InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28)
InChIKey :IVRXNBXKWIJUQB-UHFFFAOYSA-N
SMILES :N1C2C(=CC(C(N)=O)=CC=2)C(C2C(C3=NC(C)=CC=C3)=NN3CCCC3=2)=CC=1
CAS DataBase Reference :700874-72-2

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning		P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning		P264, P280, P305+P351+P338,P337+P313P

Precautionary statements:

P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P337+P313	IF eye irritation persists: Get medical advice/attention.

Description

LY2157299 is a small molecule inhibitor of the TGF-β receptor type 1 kinase (IC50 = 56 nM). It has been used to study the role of TGF-β signaling in chemotherapy-induced expansion of cancer stem-like cells in triple negative breast cancer cell lines and xenografts. LY2157299 has also been shown to inhibit the migration and tumor growth of hepatocellular carcinoma cell lines by disrupting Smad-2 phosphorylation.

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Suppliers and manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Galunisertib CAS:700874-72-2

career henan chemical co

$2.00
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TargetMol Chemicals Inc.

$40.00
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Capot Chemical Co.,Ltd.

ATK CHEMICAL COMPANY LIMITED

Biochempartner

BOC Sciences

Alchem Pharmtech,Inc.

CONIER CHEM AND PHARMA LIMITED

Dideu Industries Group Limited

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LY 2157299

Properties

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Description

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