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Furo[2,3-d]pyrimidin-4-amine (9CI)

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Furo[2,3-d]pyrimidin-4-amine (9CI) Basic information
Product Name:Furo[2,3-d]pyrimidin-4-amine (9CI)
Synonyms:Furo[2,3-d]pyrimidin-4-amine (9CI);4-Aminofuro[2,3-d]pyrimidine;Furo[2,3-d]pyrimidin-4-amine;furo[3,2-d]pyrimidin-4-amine;Furo[2,3-d]pyrimidin-4-amine (9CI) ISO 9001：2015 REACH
CAS:186454-70-6
MF:C6H5N3O
MW:135.12
EINECS:
Product Categories:PYRIMIDINE
Mol File:186454-70-6.mol
Furo[2,3-d]pyrimidin-4-amine (9CI) Structure
Furo[2,3-d]pyrimidin-4-amine (9CI) Chemical Properties
Boiling point 291 ºC
density 1.421
Fp 130 ºC
storage temp. 2-8°C(protect from light)
pka4.83±0.30(Predicted)
Safety Information
MSDS Information
Furo[2,3-d]pyrimidin-4-amine (9CI) Usage And Synthesis
Synthesis
3-Furancarbonitrile,2-amino-(9CI)

139370-56-2

formamide

77287-34-4

Furo[2,3-d]pyrimidin-4-amine (9CI)

186454-70-6

Step 2. Synthesis of furo[2,3-d]pyrimidin-4-amine (C2). 2-Aminofuran-3-carbonitrile (C1, 100 mg, 0.925 mmol) was dissolved in formamide (2 mL) and the reaction mixture was heated at 120 °C overnight. After completion of the reaction, the mixture was cooled to room temperature and subsequently partitioned between water and ethyl acetate. The aqueous layer was extracted with ethyl acetate and dichloromethane, respectively. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated in vacuum to give a yellow solid product. Yield: 21 mg, 0.16 mmol, 17% yield.LC-MS (m/z): 135.9 [M + H]+.1H NMR (400 MHz, CD3OD) δ 8.13 (s, 1H), 7.61 (d, J = 2.5 Hz, 1H), 6.89 (d, J = 2.5 Hz, 1H).

References[1] Patent: WO2015/162518, 2015, A1. Location in patent: Page/Page column 107
Furo[2,3-d]pyrimidin-4-amine (9CI) Preparation Products And Raw materials
Raw materials3-Furancarbonitrile,2-amino-(9CI)-->formamide
Tag:Furo[2,3-d]pyrimidin-4-amine (9CI)(186454-70-6) Related Product Information
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