GPX4-IN-5 manufacturers
- GPX4-IN-5
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- $43.00
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2026-08-16
- CAS:2922824-09-5
- Purity: 99.89%
- Supply Ability: 10g
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| | GPX4-IN-5 Basic information |
| Product Name: | GPX4-IN-5 | | Synonyms: | GPX4-IN-5;2-Chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-N-(4-fluoro-3,5-dimethoxyphenyl)acetamide;Acetamide, 2-chloro-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(4-fluoro-3,5-dimethoxyphenyl)-;GPX4-IN-5, 10 mM in DMSO;2-chloro-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(4-fluoro-3,5-dimethoxyphenyl)-acetamide | | CAS: | 2922824-09-5 | | MF: | C18H17ClFNO5 | | MW: | 381.78 | | EINECS: | | | Product Categories: | | | Mol File: | 2922824-09-5.mol |  |
| | GPX4-IN-5 Chemical Properties |
| Boiling point | 632.5±55.0 °C(predicted) | | density | 1.362±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | solubility | DMF: 1 mg/ml
DMSO: 1 mg/ml
Ethanol: Slightly Soluble | | pka | -4.45±0.20(predicted) | | form | Solid | | color | White to light brown |
| | GPX4-IN-5 Usage And Synthesis |
| Uses | GPX4-IN-5 (Compound C18) is a GPX4 covalent inhibitor with an IC50 value of 0.12 μM. GPX4-IN-5 (Compound C18) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) [1]. | | References | [1] Chen T, et al. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66(14):10036-10059. DOI:10.1021/acs.jmedchem.3c00967 |
| | GPX4-IN-5 Preparation Products And Raw materials |
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