- Sciadopitysin
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- $44.00 / 1mg
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2026-04-13
- CAS:521-34-6
- Min. Order:
- Purity: 99.08%
- Supply Ability: 10g
- Sciadopitysin
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- $0.00 / 20mg
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2023-02-24
- CAS:521-34-6
- Min. Order: 20mg
- Purity: ≥98%(HPLC)
- Supply Ability: 100 g
- SCIADOPITYSIN
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- $350.00 / 10KG
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2019-07-06
- CAS:521-34-6
- Min. Order: 1KG
- Purity: 99.5%
- Supply Ability: 10000kg
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| | SCIADOPITYSIN Basic information |
| Product Name: | SCIADOPITYSIN | | Synonyms: | AMENTOFLAVONE-7,4',4'''-TRIMETHYL ETHER;AMENTOFLAVONE-7,4',4''-TRIMETHYL ETHER;AMENTOFLAVONE-7,4',4'-TRIMETHYL ETHER;SCIADOPITYSIN;5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4-benzopyrone;SCIADOPITYSIN(SH);AMENTOFLAVONE-7,4'',4''-TRIMETHYL ETHER WITH HPLC;2-(4-Methoxyphenyl)-5,7-dihydroxy-8-[2-methoxy-5-(4-oxo-5-hydroxy-7-methoxy-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one | | CAS: | 521-34-6 | | MF: | C33H24O10 | | MW: | 580.54 | | EINECS: | 208-311-5 | | Product Categories: | Tri-substituted Flavones | | Mol File: | 521-34-6.mol |  |
| | SCIADOPITYSIN Chemical Properties |
| Melting point | 296-298°C | | Boiling point | 839.6±65.0 °C(Predicted) | | density | 1.445±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in ethanol and methan | | pka | 6.16±0.40(Predicted) | | form | powder | | color | Light yellow | | Major Application | food and beverages | | InChIKey | YCXRBCHEOFVYEN-UHFFFAOYSA-N | | SMILES | C1(C2=CC=C(OC)C=C2)OC2=C(C3=CC(C4OC5=CC(OC)=CC(O)=C5C(=O)C=4)=CC=C3OC)C(O)=CC(O)=C2C(=O)C=1 | | LogP | 5.500 (est) | | CAS DataBase Reference | 521-34-6 |
| Safety Statements | 24/25 | | WGK Germany | WGK 3 | | HS Code | 29329990 | | Storage Class | 11 - Combustible Solids |
| | SCIADOPITYSIN Usage And Synthesis |
| Description | Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities. It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; ) in PC12 cells (EC50 = 9.84 μM). Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells. It inhibits P-glycoprotein (P-gp; IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells. Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss. | | Chemical Properties | White crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from ginkgo leaves and yew branches and leaves. | | Uses | Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba[1]. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1[2]. | | Definition | ChEBI: A biflavonoid that is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone. | | in vivo | Sciadopitysin (i.p.; 10 mg/kg; every other day for 8 days) can reverse the bone loss in LPS-induced mice model (C57BL/6 mice; 6 weeks old)[2]. | | target | ROS | MMP(e.g.TIMP) | NO | TNF-α | ATPase | cAMP | Beta Amyloid | | IC 50 | NF-κB | | References | [1] Brianon-Scheid F, et al. HPLCSeparationandQuantitativeDeterminationofBiflavonesinLeavesfromGinkgo biloba. Planta Med.1983 Dec;49(12):204-7. DOI:10.1055/s-2007-969851
[2] SciadopitysinsuppressesRANKL-mediatedosteoclastogenesisandpreventsbonelossinLPS-treatedmice. Int Immunopharmacol.2017 Aug;49:109-117. DOI:10.1016/j.intimp.2017.05.029 |
| | SCIADOPITYSIN Preparation Products And Raw materials |
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