- 3-iodofluorobenzene
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- $250.00 / 1KG
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2025-09-30
- CAS:1121-86-4
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 20 tons
- 1-Fluoro-3-iodobenzene
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- $100.00 / 1KG
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2025-09-25
- CAS:1121-86-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- 1-Fluoro-3-iodobenzene
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- $0.00 / 25KG
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2025-08-13
- CAS:1121-86-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
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| | 1-Fluoro-3-iodobenzene Basic information |
| | 1-Fluoro-3-iodobenzene Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | TSCA | T | | HazardClass | IRRITANT | | HS Code | 29039990 |
| | 1-Fluoro-3-iodobenzene Usage And Synthesis |
| Chemical Properties | clear yellow or pink liquid | | Uses | 3-Fluoroiodobenzene was used to prepare methyl 4-iodobenzo[b]thiophene-2-carboxylate, key intermediate for the synthesis of 4-substituted benzo[b]thiophene-2-carboxamidines. | | General Description | 3-Fluoroiodobenzene participates in palladium-catalyzed hydroarylation of arylpropiolamides. | | Synthesis | The general procedure for the synthesis of m-fluoroiodobenzene from 3-fluoroaniline was as follows: an aqueous solution (20 mL) of NaNO2 (6.4 g, 92.75 mmol) was slowly added dropwise at 0 °C to a solution of 3-fluoroaniline (10 g, 90.09 mmol) dissolved in 32% H2SO4 (179 g). The reaction mixture was stirred continuously at 0 °C for 1 hour. Subsequently, an aqueous solution (30 mL) of KI (22.4 g, 134.94 mmol) was added while maintaining 0 °C and stirring was continued at 0 °C for 1 hour. After completion of the reaction, the aqueous phase was extracted with EtOAc (2 x 250 mL). The organic phases were combined and washed sequentially with water (5×200mL) and 10% NaHSO3 solution (3×200mL), dried over Na2SO4 and concentrated under reduced pressure to remove the solvent, yielding 17.7 g of 1-fluoro-3-iodobenzene as a yellow solid in 82% yield. | | References | [1] Patent: WO2008/103615, 2008, A1. Location in patent: Page/Page column 40
[2] Journal of the American Chemical Society, 1963, vol. 85, p. 709 - 724 |
| | 1-Fluoro-3-iodobenzene Preparation Products And Raw materials |
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