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Hydroxy-PEG5-acid manufacturers
- Hydroxy-PEG5-acid
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2025-06-07
- CAS:2079768-50-4
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
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| | Hydroxy-PEG5-acid Basic information |
| Product Name: | Hydroxy-PEG5-acid | | Synonyms: | HO-PEG5-CH2CH2COOH;Propanoic acid, 3-[(14-hydroxy-3,6,9,12-tetraoxatetradec-1-yl)oxy]-;Hydroxy-PEG5-propionic acid;HO-PEG5-CH2CH2COOH/Propanoic acid, 3-[(14-hydroxy-3,6,9,12-tetraoxatetradec-1-yl)oxy]-;1-Hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oic acid;HO-PEG5-COOH;ol-PEG5-acid | | CAS: | 2079768-50-4 | | MF: | C13H26O8 | | MW: | 310.34 | | EINECS: | | | Product Categories: | | | Mol File: | 2079768-50-4.mol |  |
| | Hydroxy-PEG5-acid Chemical Properties |
| Boiling point | 455.7±45.0 °C(Predicted) | | density | 1.162±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | pka | 4.28±0.10(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | Hydroxy-PEG5-acid Usage And Synthesis |
| Description | Hydroxy-PEG5-acid is a PEG derivative containing a hydroxyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. | | Uses | Hydroxy-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Hydroxy-PEG5-acid Preparation Products And Raw materials |
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