- FMOC-DAB-OH HCL
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2026-07-01
- CAS:161420-87-7
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 2000
- FMOC-DAB-OH HCL
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- $1.00
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2019-07-06
- CAS:161420-87-7
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1kg,5kg,100kg
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| | FMOC-DAB-OH HCL Basic information |
| Product Name: | FMOC-DAB-OH HCL | | Synonyms: | FMOC-L-2,4-DIAMINOBUTYRIC ACID;FMOC-L-ALPHA,GAMMA-DIAMINOBUTYRIC ACID;FMOC-DAB-OH HCL;FMOC-ALPHA,GAMMA-DIAMINOBUTYRIC ACID;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-2,4-DIAMINOBUTYRIC ACID;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ALPHA, GAMMA-DIAMINOBUTYRIC ACID;N-ALPHA-FMOC-L-ALPHA,GAMMA-DIAMINOBUTYRIC ACID;N-α-Fmoc-L-2,4-diaminobutyric acid | | CAS: | 161420-87-7 | | MF: | C19H20N2O4 | | MW: | 340.37 | | EINECS: | | | Product Categories: | | | Mol File: | 161420-87-7.mol |  |
| | FMOC-DAB-OH HCL Chemical Properties |
| Melting point | 169.5-171.7 °C | | Boiling point | 593.7±50.0 °C(Predicted) | | density | 1.294±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | form | Powder | | pka | 3.52±0.10(Predicted) | | color | White to off-white |
| | FMOC-DAB-OH HCL Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of Fmoc-L-2,4-diaminobutyric acid (Fmoc-Dab-OH) from (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-amino-5-oxopentanoic acid (Fmoc-Gln-OH) was as follows:
A. 100 g (271.5 mmol) of Fmoc-Gln-OH was suspended in 2 L of a solvent mixture consisting of ethyl acetate, acetonitrile and water in the ratio of 2:1:1 by volume. 105.1 g (325.9 mmol) of diisopropylethylamine (DIPA) was slowly added at 20-30 °C and the reaction lasted for 72 hours. Upon completion of the reaction, 80 g of Fmoc-Dab-OH was obtained after post-processing in 86.5% yield. The product was analyzed by high performance liquid chromatography (HPLC) showing a purity of 99.6%, and its structural correctness was confirmed by infrared spectroscopy (IR) and nuclear magnetic resonance (NMR), and the relevant spectra are shown in Figures 1 and 2. | | References | [1] Bulletin of the Chemical Society of Japan, 2004, vol. 77, # 10, p. 1915 - 1924
[2] Patent: CN105348147, 2016, A. Location in patent: Paragraph 0014
[3] Synlett, 2011, # 13, p. 1917 - 1919
[4] Journal of Peptide Science, 2017, vol. 23, # 3, p. 202 - 214
[5] European Journal of Medicinal Chemistry, 1995, vol. 30, # 2, p. 115 - 122 |
| | FMOC-DAB-OH HCL Preparation Products And Raw materials |
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