- Vitamin A palmitate
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- $0.00 / 5KG/Tin
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2025-11-11
- CAS:79-81-2
- Min. Order: 10KG
- Purity: 1.7MIU; USP/EP
- Supply Ability: 1000KGS
- Vitamin A palmitate
-
- $10.00 / 1KG
-
2025-11-10
- CAS:79-81-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
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| | Vitamin A palmitate Basic information |
| Product Name: | Vitamin A palmitate | | Synonyms: | VitaminAPalmitateinOil;VITAMINAPALMITATE,LIQUIDINOIL,1MILLIONIU/G;VITAMINAPALMITATE,USP;[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenyl] hexadecanoate;VITAMIN A PALMITATE(RETINYL PALMITATE)(P);VITAMIN A PALMITATE(RETINYL PALMITATE)(RG);ALL-TRANS-RETINYLPALMITATE;Retinylpalmitat | | CAS: | 79-81-2 | | MF: | C36H60O2 | | MW: | 524.86 | | EINECS: | 201-228-5 | | Product Categories: | BAYPRESS;Vitamins and derivatives;79-81-2 | | Mol File: | 79-81-2.mol |  |
| | Vitamin A palmitate Chemical Properties |
| Melting point | 28-29℃ | | Boiling point | 546.51°C (rough estimate) | | density | 0.9668 (rough estimate) | | refractive index | 1.5250 (estimate) | | Fp | 194℃ | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly) | | form | oil | | color | Light Yellow to Yellow | | Specific Gravity | 0.90～0.93 (20℃) | | biological source | synthetic (organic) | | Water Solubility | Soluble in chloroform, ether, and vegetable oils. Insoluble in water. | | Merck | 13,10073 | | BRN | 1917366 | | Specific Activity | ~1,800,000USP units/g | | BCS Class | 4 | | Stability: | Light Sensitive | | InChIKey | VYGQUTWHTHXGQB-YFAKFODJSA-N | | LogP | 15.51 at 25℃ | | CAS DataBase Reference | 79-81-2(CAS DataBase Reference) | | NIST Chemistry Reference | Vitamin a palmitate(79-81-2) | | EPA Substance Registry System | Retinol, hexadecanoate (79-81-2) |
| Hazard Codes | T,Xn,F | | Risk Statements | 63-53-61-11 | | Safety Statements | 53-23-36/37/39-45-36/37-16-60 | | RIDADR | UN1170 - class 3 - PG 2 - Ethanol, solution | | WGK Germany | 3 | | RTECS | VH6860000 | | F | 8-10-23 | | TSCA | Yes | | HS Code | 29362100 | | Toxicity | LD50 (10 day) in mice, rats (mg/kg): 6060, 7910 orally (Kamm) |
| | Vitamin A palmitate Usage And Synthesis |
| Chemical Properties | 95.0-100.5% Absorbance @325 nm ≥0.85% | | Uses | antihypertensive | | Uses | all-trans-Retinyl Palmitate is an ester derivative of Retinol (R252000). all-trans-Retinyl Palmitate is used as a vitamin supplement in the treatment of Vitamin A deficiency. all-trans-Retinyl Palmita
te is used as an antioxidant and a source of vitamin A added to low fat milk and other dairy products. all-trans-Retinyl Palmitate is also a constituent of some topically applied skin care products | | Uses | retinyl palmitate is a skin conditioner. This retinoid is considered a milder version of retinoic acid, given its conversion properties. once on the skin, it converts to retinol, which in turn converts to retinoic acid. Physiologically, it is credited with increasing R epidermal thickness, stimulating the production of more epidermal protein, and increasing skin elasticity. Cosmetically, retinyl palmitate is used to reduce the number and depth of fine lines and wrinkles, and prevent skin roughness resulting from uV exposure. Secondary reactions such as erythema, dryness, or irritation are not associated with retinyl palmitate. It is even more effective when used in combination with glycolic acid because it achieves greater penetration. In the united States, its maximum usage level in cosmetic formulations is 2 percent. Retinyl palmitate is the ester of retinol and palmitic acid. | | Uses | vitamin A palmitate is known as a skin “normalizer.” It acts as an antikeratinizing agent, helping the skin stay soft and plump, and improving its water-barrier properties. Because of its impact on the skin’s water-barrier properties, it is useful against dryness, heat, and pollution. It is also an anti-oxidant and is suggested for use in sunscreens. Clinical studies with vitamin A palmitate indicate a significant change in skin composition, with increases in collagen, DnA, skin thickness, and elasticity. Vitamin A palmitate’s stability is superior to retinol. | | Definition | ChEBI: All-trans-retinyl palmitate is an all-trans-retinyl ester obtained by formal condensation of the carboxy group of palmitic (hexadecanoic acid) with the hydroxy group of all-trans-retinol. It is used in cosmetic products to treat various skin disorders such as acne, skin aging, wrinkles, dark spots, and also protect against psoriasis. It has a role as an Escherichia coli metabolite, a human xenobiotic metabolite and an antioxidant. It is a retinyl palmitate and an all-trans-retinyl ester. It is functionally related to an all-trans-retinol. | | General Description | Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
Retinyl palmitate belongs to a category of compounds called retinoids, which are chemically similar to vitamin A. It exhibits a beneficial effect on vision, skin and immune function, inhibits cell proliferation and prevents cancer. It is an important dietary as well as a therapeutic compound. | | Flammability and Explosibility | Non flammable | | Biochem/physiol Actions | Vitamin A palmitate is widely used in pharmaceutical applications. It is also extensively used in cosmetic formulations due to its beneficial effects on the appearance of skin and anti-oxidant properties. Vitamin A palmitate acts as a teratogen and affect vertebrate embryogenesis and regeneration. It is added as a source of vitamin A in low fat and skim milks. Vitamin A palmitate acts as a chemopreventive or antineoplastic agent.
Review: Vitamin A metabolism. | | Side effects | Vitamin A palmitate is fat-soluble and is stored in the body's fatty tissue. Therefore, excessive levels of vitamin A palmitate can lead to toxicity and liver disease. This is more likely to occur when taking supplements than when consuming them from food. People with liver disease should not take vitamin A palmitate supplements. Excessive doses of vitamin A supplements have been linked to birth defects, including malformations of the eyes, lungs, skull and heart. They are not recommended for pregnant women. Regular high doses of vitamin A letter source can lead to depression, dry skin, and muscle and joint pain. | | Safety Profile | Mildly toxic by
ingestion. An experimental teratogen.
Experimental reproductive effects. Human
mutation data reported. When heated to
decomposition it emits acrid smoke and
irritating fumes. | | Synthesis | Synthesis of (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl acetate from methyl palmitate and (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6, 8-tetraen-1-yl palmitate in the following general procedure: 3000 kg of vitamin A acetate (compound of formula Ia) in crystalline form and 2750 kg of methyl palmitate (compound of formula Ia) were added to the reactor. Subsequently, 10 kg of sodium hydroxide was dissolved in about 60 liters of methanol and this solution was added to the above mixture. The reaction mixture was heated to 55°C and the system pressure was reduced to 1500-2200 Pascal. The reaction lasted for about 3 hours, during which time the main by-product, methyl acetate, was continuously removed by distillation. Reaction termination was achieved by addition of water and carbon dioxide. Finally, the target product vitamin A palmitate (compound of formula IIIa) was isolated from the reaction solution by extraction in 96% yield. | | Purification Methods | The palmitate is separated from retinol by column chromatography on water-deactivated alumina with hexane containing a very small percentage of acetone. It is also chromatographed on TLC silica gel G, using pet ether/isopropyl ether/acetic acid/water (180:20:2:5) or pet ether/acetonitrile/acetic acid/water (190:10:1:15) to develop the chromatogram. It is then recrystallised from propylene at low temperature (below -47o). [Beilstein 6 IV 4135.] | | References | [1] Patent: WO2014/23772, 2014, A1. Location in patent: Page/Page column 9 |
| | Vitamin A palmitate Preparation Products And Raw materials |
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