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| | 3,4-Difluorobenzyl bromide Basic information | | Synthesis |
| Product Name: | 3,4-Difluorobenzyl bromide | | Synonyms: | a-Bromo-3,4-difluorotoluene;1-(Bromomethyl)-3,4-difluorobenzene;1,2-Difluoro-4-(bromomethyl)benzene;Benzene, 4-(bromomethyl)-1,2-difluoro-;alpha-Bromo-3,4-difluorotoluene,98%;3,4-Difluoro Bromine Benzyl;4-(Bromomethyl)-1,2-difluorobenzene, alpha-Bromo-3,4-difluorotoluene;3,4-Difluorobenzyl b | | CAS: | 85118-01-0 | | MF: | C7H5BrF2 | | MW: | 207.02 | | EINECS: | 285-653-1 | | Product Categories: | Aromatic Halides (substituted);Miscellaneous;Fluorinated benzene series;Aryl;Aryl Fluorinated Building Blocks;Building Blocks;C7;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Hydrocarbons;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Halogenated Heterocycles ,Heterocyclic Acids;Fluorine series;Fluoro-contained benzyl bromide series | | Mol File: | 85118-01-0.mol |  |
| | 3,4-Difluorobenzyl bromide Chemical Properties |
| Boiling point | 59-61°C 3,5mm | | density | 1.618 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.526(lit.) | | Fp | 175 °F | | storage temp. | Storage temp. 2-8°C | | form | clear liquid | | Specific Gravity | 1.63 | | color | Colorless to Red to Green | | Sensitive | Lachrymatory | | BRN | 742578 | | InChI | 1S/C7H5BrF2/c8-4-5-1-2-6(9)7(10)3-5/h1-3H,4H2 | | InChIKey | JJIFTOPVKWDHJI-UHFFFAOYSA-N | | SMILES | Fc1ccc(CBr)cc1F | | CAS DataBase Reference | 85118-01-0(CAS DataBase Reference) |
| Hazard Codes | C,Xi | | Risk Statements | 34-36/37-36 | | Safety Statements | 23-26-27-36/37/39-45 | | RIDADR | UN 3265 8/PG 2 | | WGK Germany | 3 | | Hazard Note | Corrosive/Lachrymatory | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29039990 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Eye Dam. 1
Skin Corr. 1B
STOT SE 3 |
| | 3,4-Difluorobenzyl bromide Usage And Synthesis |
| Synthesis | Triphenylphosphine was slowly added to a solution of N-bromosuccinimide in dichloromethane. The resulting mixture was stirred continuously at 0°C, then refluxed at 60°C with stirring for 15 minutes. After the reaction was complete, the reaction mixture was cooled to room temperature, and then benzyl alcohol was added to the cooled reaction mixture. The mixture was stirred under reflux for 30 minutes. After the reaction was complete, the reaction mixture was concentrated, and the residue was purified by silica gel column chromatography to obtain the target product 3,4-difluorobenzyl bromide.  Figure 3,4-Difluorobenzyl bromide | | Chemical Properties | clear yellow liquid | | Uses | 3,4-Difluorobenzyl bromide has been used in the synthesis of series of benzothiophene-based phosphonates. |
| | 3,4-Difluorobenzyl bromide Preparation Products And Raw materials |
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