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4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine

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4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Basic information
Product Name:4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine
Synonyms:4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine;2-Thiazolamine, 4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-;Avatrombopag Impurity 13;5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine4-(4-chlorothiophen-2-yl)-;Avatrombopag Impurity 47;Avatroposide impurities19;4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-y1)thiazol-2-amine;4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine (Avatrombopag Impurity)
CAS:570407-42-0
MF:C17H23ClN4S2
MW:382.97
EINECS:
Product Categories:Intermediate;Intermediate
Mol File:570407-42-0.mol
4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Structure
4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Chemical Properties
Boiling point 560.0±50.0 °C(Predicted)
density 1.345±0.06 g/cm3(Predicted)
pka7.58±0.70(Predicted)
InChIInChI=1S/C17H23ClN4S2/c18-12-10-14(23-11-12)15-16(24-17(19)20-15)22-8-6-21(7-9-22)13-4-2-1-3-5-13/h10-11,13H,1-9H2,(H2,19,20)
InChIKeyFQQOPZRSAIEOGH-UHFFFAOYSA-N
SMILESS1C(N2CCN(C3CCCCC3)CC2)=C(C2SC=C(Cl)C=2)N=C1N
Safety Information
MSDS Information
4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Usage And Synthesis
Uses4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine is a valuable organic compound that could be used as an intermediate to synthesize thrombopoietin
Synthesis4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine is synthesize from the reacton of 4- (4-Chloro-2-thienyl) -5-bromo-2-thiazolylamine with cyclohexylpiperazine. The reaction mixture was extracted with water and EtOAc. The combined organic phases were washed with distilled water and brine and dried to afford 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine.
4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine
4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Preparation Products And Raw materials
Tag:4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine(570407-42-0) Related Product Information
Unii-4U07F515lg Eltrombopag Ibopamine Hydrochloride Lusutrombopag Avatrombopag Avatrombopag maleate 4-(4-Chloro-2-thienyl)-2-thiazolamine 5-bromo-4-(4-chlorothiophen-2-yl)thiazol-2-amine 1-Cyclohexylpiperazine