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| | 3-Trifluoromethylpyridine Basic information | | Synthesis |
| | 3-Trifluoromethylpyridine Chemical Properties |
| Boiling point | 113-115 °C (lit.) | | density | 1.276 g/mL at 25 °C | | refractive index | n20/D 1.418 | | Fp | 74 °F | | storage temp. | Inert atmosphere,Room Temperature | | form | clear liquid | | pka | 2.80±0.10(Predicted) | | color | Colorless to Light yellow | | BRN | 1563102 | | InChI | InChI=1S/C6H4F3N/c7-6(8,9)5-2-1-3-10-4-5/h1-4H | | InChIKey | JTZSFNHHVULOGJ-UHFFFAOYSA-N | | SMILES | C1=NC=CC=C1C(F)(F)F | | CAS DataBase Reference | 3796-23-4(CAS DataBase Reference) | | NIST Chemistry Reference | 3-(CF3)-pyridine(3796-23-4) |
| Hazard Codes | T,Xi,F | | Risk Statements | 10-25-36/37/38-11 | | Safety Statements | 26-45-37-36 | | RIDADR | UN 1992 3/PG 3 | | WGK Germany | 2 | | Hazard Note | Irritant | | HazardClass | 3 | | PackingGroup | II | | HS Code | 2933399990 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 2 Oral
Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3 |
| | 3-Trifluoromethylpyridine Usage And Synthesis |
| Synthesis | Use copper iodide (I) (13.3 mg, 0.07 mmol), 1,10-phenanthroline (12.6 mg, 0.07 mmol), KF (61 mg, 1.05 mmol, 3 eq.), and aryl iodide (0.35 mmol, 1 eq.). Close the reaction vessel, then evacuate and refill three times with argon or nitrogen. Add DMSO (1.0 mL) and aryl iodide (0.35 mmol) (if it is not solid), B(OMe)3 (109 mg, 117 μL, 1.05 mmol, 3 eq.), and TMSCF3 (149.3 mg, 155 μL, 1.05 mmol, 3 eq.) via syringe. (eq.). The solid aryl iodide was weighed directly in the reaction vessel. The resulting orange-yellow suspension was stirred at 60°C for 24 hours. The sample was dissolved in Et₂O and analyzed by GC-MS to obtain 3-trifluoromethylpyridine, yield: 100%. | | Chemical Properties | Colorless liquid;Pale yellow liqui | | Uses | 3-(Trifluoromethyl)pyridine is a reagent used to improve amyloid detection in the brain during MRI. |
| | 3-Trifluoromethylpyridine Preparation Products And Raw materials |
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