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| | Butanoic acid, 4,4'-[2,4-pyrimidinediylbis(4,1-phenyleneimino)]bis[4-oxo- (9CI) Basic information |
| Product Name: | Butanoic acid, 4,4'-[2,4-pyrimidinediylbis(4,1-phenyleneimino)]bis[4-oxo- (9CI) | | Synonyms: | Butanoic acid, 4,4'-[2,4-pyrimidinediylbis(4,1-phenyleneimino)]bis[4-oxo- (9CI);SHMT inhibitor Hit 1;4,4'-((Pyrimidine-2,4-diylbis(4,1-phenylene))bis(azanediyl))bis(4-oxobutanoic acid);SHMT-IN-3 | | CAS: | 330638-43-2 | | MF: | C24H22N4O6 | | MW: | 462.45 | | EINECS: | | | Product Categories: | | | Mol File: | 330638-43-2.mol | ![Butanoic acid, 4,4'-[2,4-pyrimidinediylbis(4,1-phenyleneimino)]bis[4-oxo- (9CI) Structure](CAS/20211123/GIF/330638-43-2.gif) |
| | Butanoic acid, 4,4'-[2,4-pyrimidinediylbis(4,1-phenyleneimino)]bis[4-oxo- (9CI) Chemical Properties |
| Boiling point | 787.0±60.0 °C(Predicted) | | density | 1.410±0.06 g/cm3(Predicted) | | pka | 4.50±0.10(Predicted) |
| | Butanoic acid, 4,4'-[2,4-pyrimidinediylbis(4,1-phenyleneimino)]bis[4-oxo- (9CI) Usage And Synthesis |
| Uses | SHMT-IN-3 (Hit 1) is a SHMT1 and SHMT2 inhibitor with an IC50 of 0.53μM for human SHMT1. SHMT-IN-3 exhibits noncompetitive inhibition against serine[1]. | | IC 50 | Human SHMT1: 0.53 μM (IC50) | | References | [1] Hiroshi Nonaka, et al. Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction. Nat Commun. 2019 Feb 20;10(1):876. DOI:10.1038/s41467-019-08833-7 |
| | Butanoic acid, 4,4'-[2,4-pyrimidinediylbis(4,1-phenyleneimino)]bis[4-oxo- (9CI) Preparation Products And Raw materials |
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