SHMT-IN-2 manufacturers
- SHMT-IN-2
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- $74.00
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2026-07-15
- CAS:2102681-49-0
- Purity: 99.79%
- Supply Ability: 10g
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| | SHMT-IN-2 Basic information |
| Product Name: | SHMT-IN-2 | | Synonyms: | Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-2,4-dihydro-3-methyl-4-(1-methylethyl)-4-[3-(1-pyrrolidinyl)-5-(trifluoromethyl)phenyl]-;SHMT-IN-2;SHMT-IN-2, 10 mM in DMSO;6-Amino-4-isopropyl-3-methyl-4-(3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile;SHIN2 | | CAS: | 2102681-49-0 | | MF: | C22H24F3N5O | | MW: | 431.45 | | EINECS: | | | Product Categories: | APIS | | Mol File: | 2102681-49-0.mol |  |
| | SHMT-IN-2 Chemical Properties |
| Boiling point | 621.2±55.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 100 mg/mL (231.78 mM; Need ultrasonic) | | pka | 11.77±0.70(Predicted) | | form | Solid | | color | White to off-white |
| | SHMT-IN-2 Usage And Synthesis |
| Uses | SHMT-IN-2 is a stereo specific inhibitor of human SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas[1]. | | References | [1] regory S Ducker, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. DOI:10.1073/pnas.1706617114 |
| | SHMT-IN-2 Preparation Products And Raw materials |
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