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| | SHMT-IN-4 Basic information |
| Product Name: | SHMT-IN-4 | | Synonyms: | SHMT-IN-4;1,4-Benzenedicarboxylic acid, 2-[[2-[4-[2-(4-bromo-2-chlorophenoxy)acetyl]-1-piperazinyl]acetyl]amino]-, 1,4-dimethyl ester | | CAS: | 3014814-72-0 | | MF: | C24H25BrClN3O7 | | MW: | 582.83 | | EINECS: | | | Product Categories: | | | Mol File: | 3014814-72-0.mol |  |
| | SHMT-IN-4 Chemical Properties |
| Boiling point | 756.6±60.0 °C(predicted) | | density | 1.491±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 13.56±0.70(predicted) |
| | SHMT-IN-4 Usage And Synthesis |
| Uses | SHMT-IN-4 (Compound 9ay) is a herbicide that targets and inhibits serine hydroxymethyltransferase (SHMT1) with an IC50 value of 193.8 g a.i./ha (active ingredient content per hectare). SHMT-IN-4 interferes with amino acid synthesis and metabolism in plants by binding to SHMT1, thereby inhibiting plant growth. Additionally, SHMT-IN-4 shows no significant toxicity to maize and honeybees[1]. | | References | [1] Luo D, et al. A first-in-class dimethyl 2-acetamido terephthalate inhibitor targeting Conyza canadensis SHMT1 with a novel herbicidal mode-of-action. J Adv Res. 2024 Aug;62:59-70. DOI:10.1016/j.jare.2023.10.003 |
| | SHMT-IN-4 Preparation Products And Raw materials |
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