- 5,6-Dimethoxyindole
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2023-12-04
- CAS:14430-23-0
- Min. Order: 1kg
- Purity: 99% hplc
- Supply Ability: 1000 kg
- 5,6-Dimethoxyindole
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2022-01-27
- CAS:14430-23-0
- Min. Order: 1KG
- Purity: 97.4%
- Supply Ability: 100 tons
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| | 5,6-Dimethoxyindole Basic information |
| Product Name: | 5,6-Dimethoxyindole | | Synonyms: | 5,6-Dimethoxyindole,99%;5,6-Dimethoxy-1H-indole 99%;5,6-Dimethoxy-1H-indole99%;AKOS JY2083477;5,6-DIMETHOXYINDOLE;1H-Indole, 5,6-dimethoxy-;5,6-Dimethoxyindole 99%;5,6-dimethoxy-1H-indole - [D82930] | | CAS: | 14430-23-0 | | MF: | C10H11NO2 | | MW: | 177.2 | | EINECS: | 238-402-5 | | Product Categories: | Amines;Aromatics;Heterocyclic Compounds;Indole Derivatives;Building Blocks;Heterocyclic Building Blocks;Indoles;Indoles and derivatives;Indoline & Oxindole | | Mol File: | 14430-23-0.mol |  |
| | 5,6-Dimethoxyindole Chemical Properties |
| Melting point | 154-157 °C (lit.) | | Boiling point | 198°C 8mm | | density | 1.182±0.06 g/cm3(Predicted) | | Fp | 198°C/8mm | | storage temp. | Sealed in dry,Room Temperature | | pka | 16.93±0.30(Predicted) | | form | Powder | | color | Beige | | Water Solubility | Insoluble in water. | | λmax | 306nm(EtOH)(lit.) | | BRN | 5683 | | InChI | InChI=1S/C10H11NO2/c1-12-9-5-7-3-4-11-8(7)6-10(9)13-2/h3-6,11H,1-2H3 | | InChIKey | QODBZRNBPUPLEZ-UHFFFAOYSA-N | | SMILES | N1C2=C(C=C(OC)C(OC)=C2)C=C1 | | CAS DataBase Reference | 14430-23-0(CAS DataBase Reference) |
| Hazard Codes | Xi | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | F | 10 | | HazardClass | IRRITANT | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids |
| | 5,6-Dimethoxyindole Usage And Synthesis |
| Chemical Properties | Beige powder | | Uses | 5,6-Dimethoxyindole is an indole derivative as analgesic antiinflammatory. It was used in the synthesis of N-benzyl-N-cyclopropyl-5,6-dimethoxyindole-3-glyoxalamide. | | Application | 5,6-Dimethoxyindole was used in the synthesis of N-benzyl-N-cyclopropyl-5,6-dimethoxyindole-3-glyoxalamide.
Reactant in synthesis of indolylhydroxyoxindoles via enantioselective Friedel-Crafts reaction
Reactant in synthesis of benzyl trimethoxyindoles
Reactant for synthesis of benzoylpiperazinyl-indolyl ethane dione derivatives as HIV-1 inhibitors
Reactant for synthesis of 1-aroylindole 3-aroylindoles combretastatin A-4 analogs as antitumor agents and tubulin polymerization inhibitors
Reactant for preparation of tryptophanol derivatives via the Grignard reaction | | Synthesis Reference(s) | Journal of the American Chemical Society, 75, p. 5887, 1953 DOI: 10.1021/ja01119a030
Synthesis of 5,6-Dimethoxyindoles and 5,6-Dimethoxyoxindoles. A New Synthesis of Indoles DOI: 10.1021/ja01619a049 | | Synthesis | The general procedure for the synthesis of 5,6-dimethoxyindole from the compound (CAS: 65907-71-3) is as follows (note: use the Biotage Initiator for microwave reactions in a 2-5 mL reaction vessel): in a microwave reactor vial, an appropriate amount of o-nitrostyrene or o-nitrocinnamate (0.3 mmol) was combined with phosphine (2.4 equiv) A suspension was formed by stirring in anhydrous solvent (5 mL) and oxygen was excluded by bubbling argon into the mixture. The vessel was sealed by adding MoO2Cl2(dmf)2 (5 mol%). The reaction mixture was heated to the indicated temperature under microwave radiation and maintained for the corresponding time. Post-reaction treatments vary depending on the phosphine used: when triphenylphosphine is used, the solvent is removed under vacuum and the product is purified by column chromatography (hexane-EtOAc); when polystyrene-loaded triphenylphosphine is used, the reaction mixture is filtered and the solvent is removed under vacuum to obtain a pure indole; when 2-(diphenylphosphino)benzoic acid is used, the reaction mixture is filtered and washed with alkali if necessary. Post-reaction treatments of other phosphines were carried out with reference to the methods described in the literature [14] [15]. | | References | [1] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1339 - 1342 |
| | 5,6-Dimethoxyindole Preparation Products And Raw materials |
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