| Company Name: |
INTATRADE GmbH |
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+49 3493/605464 |
| Email: |
sales@intatrade.de |
- 6-Methoxyindole
-
- $1.00
-
2026-10-10
- CAS:3189-13-7
- Min. Order: 1Kg
- Purity: 98%
- Supply Ability: 20T
- 6-Methoxyindole
-
-
2026-01-29
- CAS:3189-13-7
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 200kg
|
| | 6-Methoxyindole Chemical Properties |
| Melting point | 90-92 °C (lit.) | | Boiling point | 105°C 0,2mm | | density | 1.169±0.06 g/cm3(Predicted) | | Fp | 105°C/0.2mm | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Methanol (Slightly) | | pka | 17.22±0.30(Predicted) | | form | Shiny Crystals | | color | White | | Sensitive | Light Sensitive | | BRN | 116483 | | InChI | InChI=1S/C9H9NO/c1-11-8-3-2-7-4-5-10-9(7)6-8/h2-6,10H,1H3 | | InChIKey | QJRWYBIKLXNYLF-UHFFFAOYSA-N | | SMILES | N1C2=C(C=CC(OC)=C2)C=C1 | | CAS DataBase Reference | 3189-13-7(CAS DataBase Reference) | | NIST Chemistry Reference | Indole, 6-methoxy-(3189-13-7) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant/Keep Cold | | HazardClass | IRRITANT, LIGHT SENSITIVE | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 6-Methoxyindole Usage And Synthesis |
| Synthesis | 
A method for preparing quinoline and indole derivatives by catalytic oxidation and dehydrogenation of nitrogen-containing heterocyclic compounds using bio-based carbon materials, comprising the following steps:
S1. Using straw as raw material, mixing it with a dehydrating agent (e.g., P2O5, polyphosphoric acid, etc.) at a mass ratio of 1:1 to 1:8, placing it in a hydrothermal reactor with a polytetrafluoroethylene liner, reacting at 150℃-200℃ for 1-8 hours, removing it, washing it with deionized water until neutral, obtaining the catalyst;
S2. Adding 0.5 mmol of 6-methoxy-indoline and 50 mg of catalyst to a reaction tube, using oxygen as the oxidant, Using H2O as solvent, and controlling the temperature at 110℃, the reaction was carried out for 24 hours to obtain the corresponding product, 6-methoxyindole, in 83% yield.
| | Chemical Properties | white shiny crystals | | Uses | 6-Methoxyindole was used to study the fluorescence of protonated excited-state forms of serotonin and other related compounds in acid. It was used in the preparation of:
- tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles, potential anticancer immunomodulator
- indolylindazoles and indolylpyrazolopyridines, interleukin-2 inducible T cell kinase inhibitors
- diindolyloxyindoles, anticancer agents
- benzoylpiperazinyl-indolyl ethane dione derivatives, HIV-1 inhibitors
- 3-aroylindoles as anticancer agents
- indolyl and isoquinolinyl anthranilates, PPARδ partial agonists
- heteroaryl ketones, VEGFR-2 inhibitors
| | Synthesis Reference(s) | Synthesis, p. 735, 1986 DOI: 10.1055/s-1986-31759 | | Biochem/physiol Actions | 6-Methoxyindole inhibits the chlorinating activity of myeloperoxidase and inhibits the generation of hypochlorous acid released by activated leukocytes. |
| | 6-Methoxyindole Preparation Products And Raw materials |
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