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| | 4-Bromoindole-2-carboxylic acid methyl ester Basic information |
| Product Name: | 4-Bromoindole-2-carboxylic acid methyl ester | | Synonyms: | 1H-Indole-2-carboxylic acid, 4-broMo-, Methyl ester;4-bromo-1H-indole-2-carboxylic acid methyl ester;4-Bromoindole-2-carboxylic acid methyl ester;Methyl 4-bromoindole-2-carboxylate;Methyl 4-bromo-1H-indole-2-carboxylate 98%;methyl 4-bromo-1H-indole-2-carboxylate - [M83515] | | CAS: | 167479-13-2 | | MF: | C10H8BrNO2 | | MW: | 254.08 | | EINECS: | | | Product Categories: | | | Mol File: | 167479-13-2.mol |  |
| | 4-Bromoindole-2-carboxylic acid methyl ester Chemical Properties |
| Boiling point | 386.2±22.0 °C(Predicted) | | density | 1.629±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 14.04±0.30(Predicted) | | form | solid | | color | Beige |
| HazardClass | IRRITANT | | HS Code | 2924297099 |
| | 4-Bromoindole-2-carboxylic acid methyl ester Usage And Synthesis |
| Synthesis | GENERAL METHOD: Methyl 3-aryl-2-azidoacrylate (20.0 mmol) was added in a single addition to a pre-heated to reflux xylene solution (75 mL) and the reaction was kept at reflux for 2 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator. The resulting residue was purified by silica gel column chromatography with mixed petroleum ether/ethyl acetate solvent as eluent. The synthesis of compounds 12, 18 and 19 has been reported in the literature [9b, 13, 14]. | | References | [1] European Journal of Medicinal Chemistry, 2012, vol. 49, p. 379 - 396 |
| | 4-Bromoindole-2-carboxylic acid methyl ester Preparation Products And Raw materials |
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