|
|
| | QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER Basic information |
| Product Name: | QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER | | Synonyms: | Pentamethoxyquercetin;QUERCETINPENTAMETHYLETHER;PENTAMETHYLQUERCETIN;2-(3,4-Dimethoxyphenyl)-3,5,7-trimethoxy-4H-1-benzopyran-4-one;3,3',4',5,7-Pentamethoxyflavone;Quercetin 3,3',4',5,7-pentamethyl ether;3,5,7,3',4'-PENTAMETHOXYFLAVONE;QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER | | CAS: | 1247-97-8 | | MF: | C20H20O7 | | MW: | 372.37 | | EINECS: | | | Product Categories: | | | Mol File: | 1247-97-8.mol |  |
| | QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER Chemical Properties |
| Melting point | 152-156°C | | Boiling point | 561.9±50.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | form | Solid | | color | White to light brown | | LogP | 2.370 (est) |
| | QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER Usage And Synthesis |
| Uses | 3,5,7,3’,4’-Pentamethoxyflavone is a Ca2+ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases[1][2][4]. | | in vivo | 3,5,7,3’,4’-Pentamethoxyflavone (22 mg/kg; twice daily; 6 weeks; p.o.) can promote the expression of eNOS and CSE proteins in middle-aged male rats, and regulate vascular function by antagonizing the contraction of phenylephrine and enhancing the vasodilation of acetylcholine[4]. | Animal Model: | Middle-aged (12–14 month old) Wistar male rats[4]. | | Dosage: | 22 mg/kg | | Administration: | Oral gavage (p.o.); twice daily; 6 weeks | | Result: | Caused a decrease in plasma glucose and an increase in plasma HDL cholesterol levels of the rats. |
| | References | [1] Jakhar R, et al. 3,5,7,3',4'-pentamethoxyflavone, a quercetin derivative protects DNA from oxidative challenges: potential mechanism of action. J Photochem Photobiol B. 2014 Feb 5;131:96-103. DOI:10.1016/j.jphotobiol.2014.01.003
[2] Jansakul C, et al. Relaxant mechanisms of 3, 5, 7, 3', 4'-pentamethoxyflavone on isolated human cavernosum. Eur J Pharmacol. 2012 Sep 15;691(1-3):235-44. DOI:10.1016/j.ejphar.2012.07.019
[3] Mayangsari Y, et al. 3,5,7,3',4'-Pentamethoxyflavone Enhances the Barrier Function through Transcriptional Regulation of the Tight Junction in Human Intestinal Caco-2 Cells. J Agric Food Chem. 2021 Sep 8;69(35):10174-10183. DOI:10.1021/acs.jafc.1c04295
[4] Yorsin S, et al. Increased vascular eNOS and cystathionine-γ-lyase protein after 6 weeks oral administration of 3, 5, 7, 3', 4'-pentamethoxyflavone to middle-aged male rats. Naunyn Schmiedebergs Arch Pharmacol. 2016 Nov;389(11):1183-1194. DOI:10.1007/s00210-016-1280-0 |
| | QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER Preparation Products And Raw materials |
|