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| | N3-PEG4-tBu Basic information |
| Product Name: | N3-PEG4-tBu | | Synonyms: | N3-PEG4-tBu;N3-PEG4-CH2CH2COOtBu;15-Azido-4,7,10,13-tetraoxapentadecanoic acid 1,1-dimethylethyl ester;N3-PEG4-CH2CH2COOtBu;Azido-PEG5-t-butyl ester;Azido-PEG4-COOtBu;N3-?PEG4-?t-?butyl ester;Azido-PEG4-Boc | | CAS: | 581066-04-8 | | MF: | C15H29N3O6 | | MW: | 347.40726 | | EINECS: | | | Product Categories: | SiChem;peg | | Mol File: | 581066-04-8.mol |  |
| | N3-PEG4-tBu Chemical Properties |
| refractive index | 1.449 (589.3 nm 23℃) | | storage temp. | Storage temp. 2-8°C | | form | Liquid | | color | Colorless to light yellow |
| | N3-PEG4-tBu Usage And Synthesis |
| Description | Azido-PEG4-t-butyl ester is a click chemistry linker containing an azide (N3) and a t-butyl ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group is reactive toward alkyne, BCN, DBCO via Click Chemistry . The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | Azido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N3-PEG4-tBu Preparation Products And Raw materials |
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