- NH2-PEG3-OH
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2026-07-24
- CAS:6338-55-2
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
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| | NH2-PEG3-OH Basic information | | Purity |
| Product Name: | NH2-PEG3-OH | | Synonyms: | Ethanol, 2-(2-(2-aminoethoxy)ethoxy)-;AMINOETHOXY ETHOXY ETHANOL;2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL;2-[2-(2-Hydroxyethoxy)ethoxy]ethylamine;3,6,9-Trioxadecylamine;8-Amino-3,6-dioxa-1-octanol;8-Amino-3,6-dioxaoctanol;MA 10 | | CAS: | 6338-55-2 | | MF: | C6H15NO3 | | MW: | 149.19 | | EINECS: | 804-174-6 | | Product Categories: | PEG;PROTAC linker | | Mol File: | 6338-55-2.mol |  |
| | NH2-PEG3-OH Chemical Properties |
| Boiling point | 120-130℃ (4 Torr) | | density | 1.0773 g/cm3at 20℃(lit.) | | refractive index | 1.4645 (589.3 nm 20℃) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 15 mg/ml; PBS (pH 7.2): 10 mg/ml | | form | clear liquid | | pka | 14.36±0.10(Predicted) | | color | Colorless to Light yellow to Light orange | | Appearance | colorless liquid | | BRN | 1739188 | | InChI | InChI=1S/C6H15NO3/c7-1-3-9-5-6-10-4-2-8/h8H,1-7H2 | | InChIKey | ASDQMECUMYIVBG-UHFFFAOYSA-N | | SMILES | C(O)COCCOCCN | | CAS DataBase Reference | 6338-55-2 | | EPA Substance Registry System | Ethanol, 2-[2-(2-aminoethoxy)ethoxy]- (6338-55-2) |
| Hazard Codes | C,Xi | | Risk Statements | 41-34-37/38 | | Safety Statements | 26-39-45-36/37/39 | | RIDADR | 2735 | | WGK Germany | 3 | | TSCA | TSCA listed | | HazardClass | 8 | | PackingGroup | Ⅱ | | HS Code | 2922500090 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Eye Dam. 1
Skin Corr. 1B |
| | NH2-PEG3-OH Usage And Synthesis |
| Purity | ＞98% | | Description | (PEO)3-monoamine is a poly(ethylene oxide) (PEO) blocking reagent that prevents nonspecific adsorption of analytes in applications using covalent protein coupling such as ELISA. It reduces the adsorption of IgG when coated on carboxylic-terminated surfaces. | | Uses | (PEO)3-Mono-amine can be used as a novel improved cutting fluid. | | General Description | NH₂-PEG₃-OH (CAS 6338-55-2) is a high-purity, discrete, hetero-bifunctional PEG linker. Its synonyms include Amino-PEG3, Amine-PEG3-OH, (PEO)3-MONO-AMINE, Amino-PEG3-alcohol and 2-[2-(2-aminoethoxy)ethoxy]ethanol, amongst others. The NH₂-PEG₃-OH molecule consists of three parts: an amino group, a short chain comprising three PEG units, and a hydroxyl group. It can be used for peptide modification, the synthesis of small-molecule targeted drugs, ADCs and PROTACs. The amino group can react with carboxylic acids, activated NHS esters, and carbonyl groups (ketones, aldehydes); the hydroxyl group can be further converted into other functional groups. The PEG chains help to improve the solubility and stability of the drug. | | Synthesis | The general procedure for the synthesis of 2-[2-(2-aminoethoxy)ethoxy]ethanol from 2-(2-(2-azidoethoxy)ethoxy)ethanol was as follows: 2-(2-(2-azidoethoxy)ethoxy)ethanol (0.7 g, 3.99 mmol) was dissolved in methanol (9 mL), followed by addition of a palladium/activated carbon catalyst (0.196 g) under stirring conditions . The reaction flask was subjected to three evacuation/hydrogen flush cycles to establish a hydrogen atmosphere. The progress of the reaction was monitored by thin layer chromatography (TLC), which showed the completion of the reaction after 8 hours. The reaction mixture was filtered through diatomaceous earth to remove the palladium/activated carbon catalyst. The filtrate was concentrated under reduced pressure to afford 2-[2-(2-aminoethoxy)ethoxy]ethanol as a colorless oil (0.6 g, quantitative yield). | | IC 50 | PEGs | | References | [1] Helvetica Chimica Acta, 1991, vol. 74, # 8, p. 1697 - 1706
[2] Patent: US5144043, 1992, A
[3] Organic Letters, 2009, vol. 11, # 1, p. 193 - 196
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 2, p. 1151 - 1155
[5] Angewandte Chemie - International Edition, 2015, vol. 54, # 35, p. 10327 - 10330 |
| | NH2-PEG3-OH Preparation Products And Raw materials |
| Raw materials | Ethanol, 2-[2-[2-[bis(phenylmethyl)amino]ethoxy]ethoxy]--->2-[2-(2-Azidoethoxy)ethoxy]ethanol-->Ethanol, 2-[2-(2-bromoethoxy)ethoxy]--->2-(2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethyl)-isoindole-1,3-dione-->Triethylene glycol-->2-[2-(2-Chloroethoxy)ethoxy]ethanol-->(2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethyl)-carbamic acid tert-butyl ester-->Hydroxy-PEG3-Mes-->Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate)-->Hydrogen | | Preparation Products | 1,8-Diamino-3,6-dioxaoctane-->t-Boc-N-Amido-PEG3-propargyl-->1,4,7,10,13-Pentaoxa-16-azacyclooctadecane-->1OH-2BocNH-3PhPr [17]Metacyclophane deriv.-->Fmoc-NH-PEG3-CH2COOH |
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