- 3,5-Difluoroanisole
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- $0.00 / 1KG
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2025-10-21
- CAS:93343-10-3
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20 mt
- 3,5-Difluoroanisole
-
- $0.00 / 1KG
-
2025-08-19
- CAS:93343-10-3
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20tons
- 3,5-Difluoroanisole
-
- $0.00 / 1g
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2025-01-03
- CAS:93343-10-3
- Min. Order: 10mg
- Purity: 99%HPLC
- Supply Ability: 2000tons
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| | 3,5-Difluoroanisole Basic information |
| Product Name: | 3,5-Difluoroanisole | | Synonyms: | 3,5-two fluorineether;1,3-Difluoro-5-methoxybenzene, 3,5-Difluorophenyl methyl ether;1,3-difluoro-5-Methoxybenzene;3-difluoroanisile;3,5-Difluoroanisole,97%;3,5-DIFLUOROANISOLE;3,5-DIFLUORO-1-METHOXYBENZENE;Benzene, 1,3-difluoro-5-methoxy- | | CAS: | 93343-10-3 | | MF: | C7H6F2O | | MW: | 144.12 | | EINECS: | | | Product Categories: | Aromatic Ethers;Anisole;Miscellaneous;Ethers;Organic Building Blocks;Oxygen Compounds;Other fluorin-contained compounds | | Mol File: | 93343-10-3.mol |  |
| | 3,5-Difluoroanisole Chemical Properties |
| Boiling point | 145-148°C | | density | 1.234 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.466(lit.) | | Fp | 111 °F | | storage temp. | Sealed in dry,2-8°C | | form | Liquid | | Specific Gravity | 1.234 | | color | Clear colorless | | BRN | 4966844 | | CAS DataBase Reference | 93343-10-3(CAS DataBase Reference) |
| Hazard Codes | Xi,F | | Risk Statements | 10-36/37/38 | | Safety Statements | 16-26-36/37/39-7/9 | | RIDADR | UN 1993 3/PG 3 | | WGK Germany | 3 | | Hazard Note | Flammable | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29093090 |
| | 3,5-Difluoroanisole Usage And Synthesis |
| Chemical Properties | clear colorless liquid | | Uses | 3,5-Difluoroanisole is used in the preparation of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 antagonists. Also used in the preparation of imidazo[1,5-a]pyrido[3,2-e]pyrazines and imidazo[1,5-a]quinoxalines as orally active phosphodiesterase 10A inhibitors. | | General Description | The structure and vibrations of 3,5-difluoroanisole in first electronically excited state were studied by mass-analyzed resonant two-photon ionization technique as well as the quantum chemical calculations. | | Synthesis | To a stirred suspension of 3,5-difluorophenol (12.5 g, 96 mmol) and potassium carbonate (66.0 g, 480 mmol) in acetone (400 mL) was added methyl iodide (27 mL, 480 mmol) in a single addition. The reaction mixture was then heated to reflux at 60 °C for 18 hours. After cooling to room temperature, the excess solvent was evaporated under reduced pressure, 150 mL of water was added and extracted with ether (2 x 300 mL). The combined organic layers were washed sequentially with 0.1 M sodium hydroxide solution (100 mL) and water (100 mL), dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 3,5-difluoroanisole (12.0 g, 80% yield) as a colorless oil.1H-NMR (400 MHz, CDCl3) δppm: 3.81 (s, 3H), 6.43- 6.46 (m, 3H). | | References | [1] Tetrahedron Letters, 2004, vol. 45, # 1, p. 95 - 98
[2] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00138
[3] Patent: WO2017/221100, 2017, A1. Location in patent: Paragraph 00140
[4] Patent: US6149990, 2000, A |
| | 3,5-Difluoroanisole Preparation Products And Raw materials |
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