|
|
| | Bambuterol hydrochloride Basic information |
| | Bambuterol hydrochloride Chemical Properties |
| Melting point | 222-224°C | | storage temp. | Inert atmosphere,Room Temperature | | solubility | H2O: ~33 mg/mL, soluble | | form | powder | | color | off-white | | Merck | 14,953 | | Major Application | pharmaceutical (small molecule) | | InChI | 1S/C18H29N3O5.ClH/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7;/h8-10,15,19,22H,11H2,1-7H3;1H | | InChIKey | LBARATORRVNNQM-UHFFFAOYSA-N | | SMILES | Cl.CN(C)C(=O)Oc1cc(OC(=O)N(C)C)cc(c1)C(O)CNC(C)(C)C | | CAS DataBase Reference | 81732-46-9(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29242990 | | Storage Class | 11 - Combustible Solids |
| | Bambuterol hydrochloride Usage And Synthesis |
| Description | Bambuterol is an inactive prodrug of terbutaline. It has a prolonged duration
of action when administered orally. | | Chemical Properties | White Solid | | Uses | beta adrenergic agonist, bronchodilator, cholinesterase inhibitor | | Uses | Ester prodrug of the 2-adrenergic agonist terbutaline. | | Uses | Ester prodrug of the -adrenergic agonist terbutaline | | Definition | ChEBI: The hydrochloride salt of bambuterol. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline. | | Synthesis | Conventionally, as a method for preparing bambuterol hydrochloride, bis-3,5- (N, N-dimethylcarba) is subjected to an acylation process from 3 ′, 5′-dihydroxyacetophenone represented by the following reaction formula in US Pat. No. 4419364. Preparing moyloxy) -acetophenone (step 1); Preparing a bis-3 ′, 5 ′-(N, N-dimethylcarbamoyloxy) -2-bromo-acetophenone therefrom (step 2); Preparing an bis-3 ′, 5 ′-(N, N-dimethylcarbamoyloxy) -2- (N-benzyl tert-butyl) amino-acetophenone from the alkylation process therefrom (step 3); From this step to prepare a 1- [bis- (3 ', 5'-N, N-dimethylcarbamoyloxy) phenyl] -2-N-3 tert-butylaminoethanol hydrochloride, ie bambuterol hydrochloride.
 |
| | Bambuterol hydrochloride Preparation Products And Raw materials |
|