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BOC Sciences
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16314854226 |
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Product Name:WYE-23
CAS:1062169-46-3
Purity:98% Package:1G;10G;100G Remarks:WYE-23 is an inhibitor of mTOR with IC50 value of 0.45 nM.
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
| Products Intro: |
Product Name:Compound 23
CAS:1062169-46-3
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:Compound 23
CAS:1062169-46-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
TargetMol Chemicals Inc.
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15002134094 |
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marketing@targetmol.cn |
| Products Intro: |
Product Name:WYE-23
CAS:1062169-46-3
Package:1mg/RMB 1470;10mg/RMB 9870
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| | Compound 23 Basic information |
| Product Name: | Compound 23 | | Synonyms: | Compound 23;mTOR Inhibitor, WYE-23;methyl 4-(6-(4-[(cyclopropylcarbamoyl)amino]phenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate;WYE-23;1-Piperidinecarboxylic acid, 4-[6-[4-[[(cyclopropylamino)carbonyl]amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, methyl ester;4-[6-[4-[[(cyclopropylamino)carbonyl]amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylicacid,methylester | | CAS: | 1062169-46-3 | | MF: | C26H32N8O4 | | MW: | 520.58 | | EINECS: | | | Product Categories: | | | Mol File: | 1062169-46-3.mol |  |
| | Compound 23 Chemical Properties |
| density | 1.52±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | White powder solid. | | pka | 13.53±0.20(Predicted) |
| | Compound 23 Usage And Synthesis |
| Uses | mTOR inhibitor WYE-23 is a mTOR inhibitor, and IC50 is 0.45 nM. It is selective to PI3Kα and IC50 is 661 nM. mTOR inhibitor WYE-23 has antitumor activity[1][2]. | | References | [1] Nikola P. Pavletich et al. mTOR CRYSTALS AND MODULATORS. WO2014176281A1.2014-10-30.
[2] Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. DOI:10.1021/jm900851f |
| | Compound 23 Preparation Products And Raw materials |
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