N-(Azido-PEG3)-N-Boc-PEG3-NHS ester manufacturers
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| | N-(Azido-PEG3)-N-Boc-PEG3-NHS ester Basic information |
| Product Name: | N-(Azido-PEG3)-N-Boc-PEG3-NHS ester | | Synonyms: | N-(Azido-PEG3)-N-Boc-PEG3-NHS ester;(N3-PEG3)(Boc)-N-PEG3-COONHS;Boc-(N3-PEG3-CH2CH2)N-PEG3-CH2CH2COONHS;2,5-Dioxopyrrolidin-1-yl 1-azido-12-(tert-butoxycarbonyl)-3,6,9,15,18,21-hexaoxa-12-azatetracosan-24-oate | | CAS: | 2112731-51-6 | | MF: | C26H45N5O12 | | MW: | 619.6618 | | EINECS: | | | Product Categories: | | | Mol File: | 2112731-51-6.mol |  |
| | N-(Azido-PEG3)-N-Boc-PEG3-NHS ester Chemical Properties |
| | N-(Azido-PEG3)-N-Boc-PEG3-NHS ester Usage And Synthesis |
| Description | N-(Azido-PEG3)-N-Boc-PEG3-NHS ester is a branched PEGylation linker. The azide group allows for Click Chemistry reactions to take place. The Boc-protected amine can be deprotected under acidic conditions. The NHS ester can react with primary amines. | | Uses | N-(Azido-PEG3)-N-Boc-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-Boc-PEG3-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-(Azido-PEG3)-N-Boc-PEG3-NHS ester Preparation Products And Raw materials |
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