|
|
| | (5-TRIFLUOROMETHYL-PYRIDIN-2-YL) METHANOL Basic information |
| Product Name: | (5-TRIFLUOROMETHYL-PYRIDIN-2-YL) METHANOL | | Synonyms: | (5-TRIFLUOROMETHYL-PYRIDIN-2-YL) METHANOL;2-(Hydroxymethyl)-5-(trifluoromethyl)pyridine;5-(trifluoromethyl)-2-Pyridinemethanol;[5-(Trifluoromethyl)-2-pyridinyl]methanol;2-HydroxyMethyl-5-(TrifluorMethyl)-Pyridine;2-Pyridinemethanol, 5-(trifluoromethyl)-;(5-TRIFLUOROMETHYL-PYRIDIN-2-YL) METHANOL ISO 9001：2015 REACH | | CAS: | 31181-84-7 | | MF: | C7H6F3NO | | MW: | 177.12 | | EINECS: | | | Product Categories: | | | Mol File: | 31181-84-7.mol |  |
| | (5-TRIFLUOROMETHYL-PYRIDIN-2-YL) METHANOL Chemical Properties |
| Boiling point | 215.5±35.0 °C(Predicted) | | density | 1.362±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 13.16±0.10(Predicted) | | Appearance | Light yellow to yellow Liquid |
| HazardClass | IRRITANT | | HS Code | 2933399990 |
| | (5-TRIFLUOROMETHYL-PYRIDIN-2-YL) METHANOL Usage And Synthesis |
| Synthesis | IV. General procedure for the synthesis of 5-trifluoromethylpyridine-2-methanol: To a solution of methyl 5-trifluoromethylpyridine-2-carboxylate (2 g, 9.75 mmol) in methanol (30 mL) was added sodium borohydride (738 mg, 19.5 mmol) in one batch at 0 °C. The reaction mixture was stirred at room temperature for 2 hours and then concentrated. The residue was diluted with water (30 mL), acidified with 1N hydrochloric acid to pH ~5, and extracted with ethyl acetate (3 x 50 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated, and finally purified by silica gel column chromatography to afford 5-trifluoromethylpyridine-2-methanol as a colorless oil (1.6 g, 93% yield).1H NMR (400 MHz, CDCl3) δppm: 8.82 (s, 1H), 7.90-7.92 (m, 1H), 7.40-7.42 (m, 1H ), 4.82-4.83 (m, 2H), 3.44-3.46 (m, 1H); ES-LCMS m/z 178 ([M+H]+). | | References | [1] Patent: WO2013/166621, 2013, A1. Location in patent: Page/Page column 48
[2] Patent: CN106831840, 2017, A. Location in patent: Paragraph 0102; 0103; 0104
[3] Patent: US2009/124666, 2009, A1. Location in patent: Page/Page column 25-26 |
| | (5-TRIFLUOROMETHYL-PYRIDIN-2-YL) METHANOL Preparation Products And Raw materials |
|