- ETHYL 3-PYRIDYLACETATE
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- $1.10 / 1g
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2021-10-27
- CAS:39931-77-6
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
- ETHYL 3-PYRIDYLACETATE
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- $1.00 / 1KG
-
2019-08-30
- CAS:39931-77-6
- Min. Order: 1KG
- Purity: 95%-99%
- Supply Ability: 100KG
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| | ETHYL 3-PYRIDYLACETATE Basic information | | Uses |
| | ETHYL 3-PYRIDYLACETATE Chemical Properties |
| Boiling point | 80 °C/0.4 mmHg (lit.) | | density | 1.086 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.500(lit.) | | Fp | >230 °F | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Chlorofrom (Slightly), Methanol (Slightly) | | pka | 4.82±0.10(Predicted) | | form | Liquid | | color | Clear colorless to yellow | | BRN | 123827 | | InChIKey | RPWXYCRIAGBAGY-UHFFFAOYSA-N | | CAS DataBase Reference | 39931-77-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | UR8950000 | | HS Code | 29339900 |
| | ETHYL 3-PYRIDYLACETATE Usage And Synthesis |
| Uses | Ethyl 3-Pyridylacetate is a reagent in the preparation of piperidinylalkanoic acid derivatives as a potent α4β1 integrin antagonists. | | Chemical Properties | clear colorless to yellow liquid | | Uses | Ethyl 3-Pyridylacetate is a reagent in the preparation of piperidinylalkanoic acid derivatives as a potent α4β1 integrin antagonists. | | Synthesis | General procedure: After evacuation under a standard cycle and backfilling with dry pure nitrogen, palladium catalyst (see Tables 1, 2, 3, and 4 for amounts), ligand (see Tables 1, 2, 3, and 4), N,N-dimethylpyridin-4-amine (DMAP, see Tables 1, 2, 3, and 4), and monoethyl malonate potassium salt (see Tables 1, 2, 3, and 4) were added sequentially to the oven-dried Schlenk tubes fitted with a magnetic stir bar. and Table 4), and monoethyl malonate potassium salt (see Tables 1, 2, 3, and 4 for amounts). Subsequently, the Schlenk tubes were evacuated and backfilled with argon, and this process was repeated three times. Under argon protection, 3-bromopyridine (see Tables 1, 2, 3, and 4 for amounts) and solvent (see Tables 1, 2, 3, and 4 for types and amounts) were added via syringe. The Schlenk tube was sealed and stirred for 10 minutes at room temperature. After that, the Schlenk tube was connected to an argon-filled Schlenk line and placed in an oil bath preheated to 140-150°C and the reaction was stirred for 20-25 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, diluted with ether and the yield of ethyl 3-pyridylacetate was determined by gas chromatography using 1,3-dimethoxybenzene as an internal standard. | | References | [1] Tetrahedron, 2012, vol. 68, # 9, p. 2113 - 2120 |
| | ETHYL 3-PYRIDYLACETATE Preparation Products And Raw materials |
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