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| | 3-(Trimethylsilyl) propionic acid Basic information | | Uses |
| Product Name: | 3-(Trimethylsilyl) propionic acid | | Synonyms: | 3-(trimethylsilyl)-propanoicaci;Propanoic acid, 3-(trimethylsilyl)-;3-(trimethylsilyl)propionicaci;3-Trimethylsilylpropionic Acid (TMSPA) extrapure, 95%;DK827;DKFELEX0217;Lactic Acid Impurity 66 Monomer;3-(trimethylsilyl)Propanoic acid | | CAS: | 5683-30-7 | | MF: | C6H14O2Si | | MW: | 146.26 | | EINECS: | 227-145-4 | | Product Categories: | | | Mol File: | 5683-30-7.mol |  |
| | 3-(Trimethylsilyl) propionic acid Chemical Properties |
| Melting point | 22 °C | | Boiling point | 130 °C | | density | 0.92 | | refractive index | 1.4280 | | Fp | 74°C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 4.98±0.10(Predicted) | | Specific Gravity | 0.92 | | Appearance | Colorless to light yellow Liquid | | Hydrolytic Sensitivity | 1: no significant reaction with aqueous systems | | EPA Substance Registry System | 3-(Trimethylsilyl)propionic acid (5683-30-7) |
| | 3-(Trimethylsilyl) propionic acid Usage And Synthesis |
| Uses | 3-Trimethylsilylic propionic acid is a carboxylic acid. Carboxylic acids are an important class of organic compounds with wide applications in industry, agriculture, medicine, and daily life. The oxidation reaction from alcohol to acid is a fundamental and important chemical reaction in organic chemistry. In industry and pharmaceuticals, carboxylic acids are often produced through oxidation methods. | | Definition | ChEBI: An organosilicon compound that is propionic acid substituted at position 3 by a trimethylsilyl group. It is used as internal reference in the NMR spectrum nuclear magnetic resonance for aqueous solvents (e.g. D2O). | | Synthesis | Fe(NO3)3-9H2O (40.5 mg, 0.1 mmol) and DCE (4.0 mL) were added to a 100 mL round-bottomed vial followed by TEMPO (15.7 mg, 0.1 mmol), KCl (7.8 mg, 0.1 mmol), 3-trimethylsilylpropynol (128.6 mg, 1.0 mmol) and DCE ( 1.0 mL). The round-bottomed flask was connected to an air balloon via a pumping valve. The reaction was stirred at room temperature for 48 h until the reaction was monitored for completion by TLC (petroleum ether:ethyl acetate = 5:1). The reaction mixture was filtered through a short column of crude silica gel and drenched with ether (75 mL). After vacuum spin-drying of the solvent, silica gel column chromatography (petroleum ether:ethyl acetate = 5:1) was used for purification to afford 3-trimethylsilylpropynoic acid (92.9 mg, 65%) (petroleum ether:ethyl acetate = 5:1). |
| | 3-(Trimethylsilyl) propionic acid Preparation Products And Raw materials |
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