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| | 4-CYANOQUINOLINE Basic information |
| Product Name: | 4-CYANOQUINOLINE | | Synonyms: | 4-CYANOQUINOLINE;cinchoninonitrile;4-Quinolinecarbonitrile;QUINOLINE-4-CARBONITRILE | | CAS: | 2973-27-5 | | MF: | C10H6N2 | | MW: | 154.17 | | EINECS: | | | Product Categories: | | | Mol File: | 2973-27-5.mol |  |
| | 4-CYANOQUINOLINE Chemical Properties |
| Melting point | 103.5°C | | Boiling point | 267.53°C (rough estimate) | | density | 1.1975 (rough estimate) | | refractive index | 1.4820 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | pka | 1.55±0.13(Predicted) | | Appearance | White to off-white Solid |
| | 4-CYANOQUINOLINE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of quinoline-4-carbonitrile from 4-quinolinecarboxaldehyde: 4-quinolinecarboxaldehyde (54 mg, 0.5 mmol) and ammonium acetate (385 mg, 5.0 mmol) were dissolved in acetonitrile (6 mL) at room temperature, followed by the addition of trimethylphenyltrimethylammonium (376 mg, 1.0 mmol). The reaction mixture was stirred continuously for 21 hours at room temperature. Upon completion of the reaction, the reaction mixture was sequentially treated with 0.5 M Na2S2O3 aqueous solution (10 mL) and 1.0 M NaHCO3 aqueous solution (15 mL) and then extracted with ethyl acetate (60 mL). The organic phase was washed sequentially with 0.5 M Na2S2O3 aqueous solution and saturated NaCl aqueous solution and finally dried with anhydrous MgSO4. | | References | [1] Heterocycles, 2016, vol. 92, # 10, p. 1796 - 1802
[2] Patent: EP1555257, 2005, A1. Location in patent: Page/Page column 24 |
| | 4-CYANOQUINOLINE Preparation Products And Raw materials |
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