- Herbacetin
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- $39.00
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2026-07-27
- CAS:527-95-7
- Purity: 99.49%
- Supply Ability: 10g
- Herbacetin
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2023-02-24
- CAS:527-95-7
- Min. Order: 20mg
- Purity: ≥98%(HPLC)
- Supply Ability: 100 g
- Herbacetin
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2022-07-25
- CAS:527-95-7
- Min. Order: 20mg
- Purity: HPLC>99%
- Supply Ability: 1.5g
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| | Herbacetin Basic information |
| Product Name: | Herbacetin | | Synonyms: | 3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-1-benzopyran-4-one;3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one;3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one;Herbacetin, 98%, from Rhodiola rosea L.;3,5,7,8,4'-Pentahydroxyflavone/3,5,7,3',4',8-Hexahydroxyflavone - Herbacetin/Gossypetin mixture;HERBACETIN(P)(PLEASE CALL);3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Isoarticulatidin | | CAS: | 527-95-7 | | MF: | C15H10O7 | | MW: | 302.24 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Penta-substituted Flavones | | Mol File: | 527-95-7.mol |  |
| | Herbacetin Chemical Properties |
| Melting point | 284℃ | | Boiling point | 618.7±55.0 °C(Predicted) | | density | 1.799 | | storage temp. | -20°C | | solubility | DMF:30.0(Max Conc. mg/mL);99.26(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);99.26(Max Conc. mM)
DMSO:PBS(pH 7.2) (1:4):1.0(Max Conc. mg/mL);3.31(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);6.62(Max Conc. mM) | | form | A crystalline solid | | pka | 6.49±0.40(Predicted) | | color | Light yellow to yellow | | Major Application | metabolomics
vitamins, nutraceuticals, and natural products | | InChI | InChI=1S/C15H10O7/c16-7-3-1-6(2-4-7)14-13(21)12(20)10-8(17)5-9(18)11(19)15(10)22-14/h1-5,16-19,21H | | InChIKey | ZDOTZEDNGNPOEW-UHFFFAOYSA-N | | SMILES | C1(C2=CC=C(O)C=C2)OC2=C(O)C(O)=CC(O)=C2C(=O)C=1O | | LogP | 1.140 (est) |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | Herbacetin Usage And Synthesis |
| Chemical Properties | Soluble in methanol, ethanol, DMSO and other organic solvents, derived from the aerial part of Equisetum, Rhodiola rosea. | | Uses | Herbacetin is a flavonol compound, and a natural inhibitor of E.coli β-glucuronidase. Herbacetin inhibits inducible nitric oxide synthase via JNK and nuclear factor-κB in LPS-stimulated RAW264.7 cells. Molecular docking study of flavonoid compounds as an inhibitor of β-ketoacyl acyl carrier proteinsynthase II of Pseudomonas aeruginosa. | | Definition | ChEBI: Herbacetin is a pentahydroxyflavone that is kaempferol substituted by a hydroxy group at position 8. It is a natural flavonoid from flaxseed which exerts antioxidant, anti-inflammatory and anticancer activities. It has a role as an EC 4.1.1.17 (ornithine decarboxylase) inhibitor, an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor, a plant metabolite, an antilipemic drug, an anti-inflammatory agent and an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor. It is a pentahydroxyflavone and a 7-hydroxyflavonol. It is functionally related to a kaempferol. | | Biological Activity | Herbacetin is a natural flavonoid in flaxseed with a variety of pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects. Gluprotamine is an allosteric inhibitor of Ornithine decarboxylase (ODC), which directly binds to Asp44, Asp243 and Glu384 on ODC. | | Synthesis | Method of extracting Herbacetin from Rhodiola rosea, comprising the following steps;
1) extracting crushed Rhodiola rosea herbs with an extraction solvent, and concentrating the extract under reduced pressure to obtain an extract infusion;
2) extract the extract extract, the extracted aqueous layer and then acid hydrolysis;
3) The solution after acid hydrolysis is extracted with organic solvent, the extract is combined and concentrated under reduced pressure to obtain herbaceous extract;
4) the oxalic acid extract is processed by polyamide column chromatography, the stream fraction containing oxalic acid is collected, concentrated to dryness, and the crude oxalic acid is obtained;
5) The crude herbaceous material was processed by reversed-phase silica gel column chromatography, the flow fraction containing herbaceous material was collected, concentrated to dryness, and recrystallized to obtain the pure product of herbacetin material.
| | in vivo | Herbacetin (orally administration; 20mg/kg) significantly reduces the body weight, plasma glucose, plasma insulin, and HOMA-IR activity in obesity associated insulin resistant mice (OIR). (Herbacetin dissolves in 0.5% DMSO) .Herbacetin (intraperitoneal injection; 0.4, 2, 10 or 20 mg/kg; BW) decreases the number and size of polyps in APCM in+ mice with no overt toxicity. < b> |
| | Herbacetin Preparation Products And Raw materials |
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