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- Boc-Tyr-Otbu
-
-
2026-09-11
- CAS:18938-60-8
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T
- Boc-Tyr-OtBu
-
- $9.80
-
2020-01-09
- CAS:18938-60-8
- Min. Order: 1g
- Purity: ≥99%
- Supply Ability: 100kg
|
| | Boc-Tyr-OtBu Basic information |
| Product Name: | Boc-Tyr-OtBu | | Synonyms: | Boc-Tyr-OtBu;(S)-2-[(tert-Butoxycarbonyl)amino]-3-(4-hydroxyphenyl)propionic acid tert-butyl ester;Boc-L-tyrosine tert-butyl ester;N-[(1,1-Dimethylethoxy)carbonyl]-L-tyrosine 1,1-dimethylethyl ester;L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester;(Tert-Butoxy)Carbonyl Tyr-OtBu;tert-butyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-(4-hydroxyphenyl)propanoate;N-Boc-L-tyrosine tert-Butyl Ester | | CAS: | 18938-60-8 | | MF: | C18H27NO5 | | MW: | 337.41 | | EINECS: | | | Product Categories: | | | Mol File: | 18938-60-8.mol |  |
| | Boc-Tyr-OtBu Chemical Properties |
| Melting point | 111-112 °C(Solv: ligroine (8032-32-4); ethyl acetate (141-78-6)) | | Boiling point | 476.0±40.0 °C(Predicted) | | density | 1.117±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | Solid | | pka | 9.75±0.15(Predicted) | | color | White to off-white | | Optical Rotation | Consistent with structure |
| | Boc-Tyr-OtBu Usage And Synthesis |
| Uses | Boc-Tyr-OtBu is a tyrosine derivative[1]. | | Synthesis | To a solution of 9.82 g (0.041 mol) tert-butyl L-tyrosinate in 150 mL of dichloromethane and 20 mL of DMF was added 5.2 g (0.04 mol) of triethylamine, followed by 9.03 g (0.04 mol) of di-tert-butyl dicarbonate. The reaction mixture was stirred at room temperature for 2 h. Upon completion of the reaction, it was washed sequentially with 1N HCl (3 × 50 mL), saturated NaHCO3 solution (1 × 50 mL), and brine (1 × 50 mL). The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated in vacuum to give 13.59 g (98% yield) of white solid product. The structure of the product was confirmed by 300 MHz 1H NMR (CDCl3): δ 1.42 (s, 18H), 2.95 (d, 2H), 4.39 (dd, 1H), 5.01 (d, 1H), 6.15 (s, 1H), 6.70 (d, 2H), 7.00 (d, 2H). | | References | [1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368 |
| | Boc-Tyr-OtBu Preparation Products And Raw materials |
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