|
|
| | 2-Chloro-6-fluorobenzyl chloride Basic information |
| Product Name: | 2-Chloro-6-fluorobenzyl chloride | | Synonyms: | LABOTEST-BB LT02085021;AKOS BBS-00004004;2-CHLORO-6-FLUOROBENZYL CHLORIDE;1-CHLORO-2-(CHLOROMETHYL)-3-FLUOROBENZENE;Benzene, 1-chloro-2-(chloromethyl)-3-fluoro-;2-Chloro-6-Fluorochlorobenzyl;alpha,2-Dichloro-6-fluorotoluene;2,α-dichloro-6-fluorotoluene | | CAS: | 55117-15-2 | | MF: | C7H5Cl2F | | MW: | 179.02 | | EINECS: | 259-487-5 | | Product Categories: | Fluorine series;bc0001 | | Mol File: | 55117-15-2.mol |  |
| | 2-Chloro-6-fluorobenzyl chloride Chemical Properties |
| Hazard Codes | C,Xi,N | | Risk Statements | 34-51/53 | | Safety Statements | 26-36/37/39-45-61 | | RIDADR | UN 3265 8/PG 2 | | WGK Germany | 3 | | Hazard Note | Corrosive/Lachrymatory | | TSCA | TSCA listed | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29039990 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Skin Corr. 1B |
| | 2-Chloro-6-fluorobenzyl chloride Usage And Synthesis |
| Chemical Properties | clear colorless liquid | | Uses | 2-Chloro-6-fluorobenzyl chloride was used:
- as alkylating reagent during the synthesis of 3-benzylsulfanyl derivatives of 1,2,4-triazole and 4-methyl-1,2,4-triazole
- in the preparataion of 2-chloro-6-fluorobenzylamine, required for the synthesis of 9-substituted adenine
- in the preparation of aprinocid via reaction with adenine
| | Synthesis | Add 250 g of 2-chloro-6-fluorotoluene and 0.5 ml of phosphorus trichloride (the addition of phosphorus trichloride in this step can improve the quality of the product) to a 500 ml four-necked glass reaction flask equipped with a reflux condenser tube, an off-gas absorption device and a thermometer, and pass the chlorine gas under the irradiation of a metal halide lamp and keep it under the 180 Chlorine gas was passed under the condition of to obtain 2-chloro-6-fluorobenzyl chloride. Detect the content of 2-chloro-6-fluorobenzyl chloride in the liquid phase of the reaction bottle by gas chromatography, and when the content of 2-chloro-6-fluorobenzyl chloride is detected to be less than 0.5%, stop passing the chlorine gas, and simultaneously When the content of 2-chloro-6-fluorobenzyl chloride is detected to be less than 0.5%, stop passing chlorine gas, and at the same time, pass nitrogen into the reaction bottle to remove the unreacted chlorine in the bottle. |
| | 2-Chloro-6-fluorobenzyl chloride Preparation Products And Raw materials |
|