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BOC Sciences |
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16314854226 |
| Email: |
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| Company Name: |
Musechem |
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- DprE1-IN-2
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- $41.00
-
2026-07-14
- CAS:1615713-87-5
- Purity: 99.91%
- Supply Ability: 10g
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| | DprE1-IN-2 Basic information |
| Product Name: | DprE1-IN-2 | | Synonyms: | DprE1-IN-2;CS-2339;DprE1 inhibitor 2;DPRE1 INHIBITOR 2;DPRE1 IN 2;DprE1-IN-25;1H-Pyrrolo[3,2-b]pyridine-3-carboxamide, 1-[[6-(dimethylamino)-5-methyl-4-pyrimidinyl]methyl]-N-(2-hydroxyethyl)-6-methyl-;DprE1,antituberculosis,effect,DprE-1-IN-2,DprE1IN2,DprE1 IN 2,Bacterial,tuberculosis,Inhibitor,inhibit;DprE1-IN-2, 10 mM in DMSO | | CAS: | 1615713-87-5 | | MF: | C19H24N6O2 | | MW: | 368.43 | | EINECS: | | | Product Categories: | | | Mol File: | 1615713-87-5.mol |  |
| | DprE1-IN-2 Chemical Properties |
| Boiling point | 701.4±60.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 2mg/mL; DMSO: 2mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL | | form | A crystalline solid | | pka | 12.81±0.46(Predicted) | | color | White to off-white |
| | DprE1-IN-2 Usage And Synthesis |
| Uses | DprE1-IN-2 (compound 18) is a potent DprE1 inhibitor with an IC50 of 28 nM. DprE1-IN-2 has antituberculosis effect[1]. | | in vivo | DprE1-IN-2 (compound 18; oral; 100 mg/kg) has t1/2 of 0.9 hours and Cmax of 70 μM in BALB/c Mice[1]. | Animal Model: | BALB/c Mice[1] | | Dosage: | 100 mg/kg | | Administration: | Oral | | Result: | Had t1/2 of 0.9 hours and Cmax of 70 μM.
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| | References | [1] Shirude PS et al. Lead optimization of 1,4-azaindoles as antimycobacterial agents. J Med Chem. 2014 Jul 10;57(13):5728-37. DOI:10.1021/jm500571f |
| | DprE1-IN-2 Preparation Products And Raw materials |
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