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| | 1-(2-Methoxyethyl)piperazine Basic information |
| | 1-(2-Methoxyethyl)piperazine Chemical Properties |
| Melting point | 100-101 °C | | Boiling point | 193-194 °C (lit.) | | density | 0.970 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.4730(lit.) | | Fp | 188 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 9.15±0.10(Predicted) | | form | Liquid | | color | Clear colorless to yellow | | BRN | 105098 | | InChI | 1S/C7H16N2O/c1-10-7-6-9-4-2-8-3-5-9/h8H,2-7H2,1H3 | | InChIKey | BMEMBBFDTYHTLH-UHFFFAOYSA-N | | SMILES | COCCN1CCNCC1 | | CAS DataBase Reference | 13484-40-7(CAS DataBase Reference) |
| Hazard Codes | C,Xi | | Risk Statements | 34-36/37/38 | | Safety Statements | 26-36/37/39-45-37/39 | | RIDADR | UN 2735 8/PG 3 | | WGK Germany | 3 | | F | 10-34 | | Hazard Note | Irritant | | HazardClass | 8 | | PackingGroup | Ⅲ | | HS Code | 29349990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 4 Inhalation
Eye Dam. 1
Repr. 2
Skin Corr. 1B
Skin Sens. 1
STOT RE 1 |
| | 1-(2-Methoxyethyl)piperazine Usage And Synthesis |
| Chemical Properties | Clear colorless to yellow liquid | | Uses | Reactant for:• ;Preparation of biologically and pharmacologically active molecules1,2,3,4,5 | | Uses | Reactant for:
- Preparation of biologically and pharmacologically active molecules
| | Synthesis | Under nitrogen protection, 8.6 g (0.1 mol) of piperazine and 10.4 g of methanol were added to the reaction flask, 35 µl of hydrochloric acid (10.4 g, 0.1 mol) was added with stirring, and the internal temperature was controlled to 80 °C. Under the condition of keeping the internal temperature below 80 °C, 8.7 g (0.07 mol) of 2-bromoethanol was added slowly and dropwise over 0.5 h. Subsequently, the reaction was continued with stirring at the same temperature for 8 h. 36.9 g of colorless and transparent reaction solution was obtained. Gas chromatographic analysis showed a yield of 84.6% for N-(2-hydroxyethyl)piperazine, with a selectivity of 88.5% for N-(2-hydroxyethyl)piperazine, 7.7% for N,N'-bis(2-hydroxyethyl)piperazine, and 3.8% for the unknown component. Compared to the results of Example 2 in Table 1 , the reaction conditions were the same as in Example 2 when 3.8 g (0.04 mol) of 2-methoxyethyl ester was used in place of 2-bromoethanol. GC analysis showed a 70.1% yield of N-(2-methoxyethyl)piperazine with a selectivity of 83.4% for N-(2-methoxyethyl)piperazine, 15.0% for N,N'-bis(2-methoxyethyl)piperazine, and 1.6% for the unknown component. This result is consistent with the results of Example 5 in Table 1. | | References | [1] Patent: JP5838628, 2016, B2. Location in patent: Paragraph 0056; 0059 |
| | 1-(2-Methoxyethyl)piperazine Preparation Products And Raw materials |
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