|
|
| | 6-Bromo-2,3-dihydro-4H-chromen-4-one Basic information | | Uses |
| Product Name: | 6-Bromo-2,3-dihydro-4H-chromen-4-one | | Synonyms: | BUTTPARK 35\07-34;6-Bromochromanone (6-Bromochroman-4-one);6-Bromo-2,3-dihydro-4H-chromen-4-one 6-Bromo-4-chromanone;6-broMo-3,4-dihydro-2H-1-benzopyran-2-one;6-BroMo-4-chroManone 97%;4H-1-BENZOPYRAN-4-ONE, 6-BROMO-2,3-DIHYDRO-;6-BROMOCHROMANONE;6-BROMOCHROMAN-4-ONE | | CAS: | 49660-57-3 | | MF: | C9H7BrO2 | | MW: | 227.05 | | EINECS: | 663-717-3 | | Product Categories: | | | Mol File: | 49660-57-3.mol |  |
| | 6-Bromo-2,3-dihydro-4H-chromen-4-one Chemical Properties |
| Melting point | 77-83°C | | Boiling point | 336.6±42.0 °C(Predicted) | | density | 1.621±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | powder to crystal | | color | White to Orange to Green | | InChI | InChI=1S/C9H7BrO2/c10-6-1-2-9-7(5-6)8(11)3-4-12-9/h1-2,5H,3-4H2 | | InChIKey | PFLPVOXSUCCZDH-UHFFFAOYSA-N | | SMILES | C1OC2=CC=C(Br)C=C2C(=O)C1 | | CAS DataBase Reference | 49660-57-3(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | HS Code | 2914390090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 6-Bromo-2,3-dihydro-4H-chromen-4-one Usage And Synthesis |
| Uses | 4-Dihydrochromone is a class of natural compounds with excellent biological activities, including anticancer, antibacterial, anti-inflammatory, and anti-allergic activities, as well as antiplatelet aggregation activities. 6-Bromo-4-dihydrochromone is a derivative of 4-dihydrochromone and can be used as a pharmaceutical intermediate. | | Chemical Properties | Pale yellow crystalline solid | | Synthesis | 3-(4-Bromophenoxy)propionic acid (150 g, 0.61 mol) was slowly added to 1.0 liter of concentrated sulfuric acid at room temperature with continuous stirring for 1 hour. Upon completion of the reaction, the mixture was carefully poured into 500 g of ice water, whereupon a white solid precipitated. The white solid was separated by filtration and dried naturally in air. The crude product was purified by recrystallization using ethanol, resulting in 89 g (64% yield) of the target compound 6-bromobenzodihydropyran-4-one as a white solid. | | References | [1] E-Journal of Chemistry, 2012, vol. 9, # 3, p. 1251 - 1256
[2] Patent: CN106699716, 2017, A. Location in patent: Paragraph 0022; 0035
[3] Australian Journal of Chemistry, 2010, vol. 63, # 11, p. 1582 - 1593
[4] Journal of the American Chemical Society, 1951, vol. 73, p. 4205,4207
[5] Tetrahedron, 2017, vol. 73, # 27-28, p. 3913 - 3922 |
| | 6-Bromo-2,3-dihydro-4H-chromen-4-one Preparation Products And Raw materials |
|