| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
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| Tel: |
010-60605840 15801484223; |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:PROTAC BRD4 Degrader-5
CAS:2409538-70-9
Purity:98% Package:10mg
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PROTAC BRD4 Degrader-5 manufacturers
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| | PROTAC BRD4 Degrader-5 Basic information |
| Product Name: | PROTAC BRD4 Degrader-5 | | Synonyms: | PROTAC BRD4 Degrader-5;(2S,4R)-1-[(2S)-2-(2-{2-[2-(2-{2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,?]trideca-2(6),4,7,10,12-pentaen-9-yl]acetamido}ethoxy)ethoxy]ethoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide | | CAS: | 2409538-70-9 | | MF: | C50H62ClN9O8S2 | | MW: | 1016.67 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![PROTAC BRD4 Degrader-5 Structure]() |
| | PROTAC BRD4 Degrader-5 Chemical Properties |
| density | 1.38±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 145 mg/mL (142.62 mM) | | pka | 13.54±0.46(Predicted) | | form | Solid | | color | White to off-white | | Water Solubility | Water: < 0.1 mg/mL (insoluble) |
| | PROTAC BRD4 Degrader-5 Usage And Synthesis |
| Uses | PROTAC BRD4 Degrader-5 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1]. | | IC 50 | BRD4 | | References | [1] Mar A Maneiro, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312. DOI:10.1021/acschembio.0c00285 |
| | PROTAC BRD4 Degrader-5 Preparation Products And Raw materials |
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