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Related articles - A synthesis of L- Isoglutamine
- In the course of our studies on histidine metabolism it became necessary to prepare some L-isoglutamine. Swan and duVigneaud ....
- Oct 15，2019
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| | L-Glutamic acid alpha-amide Basic information | | Preparation |
| Product Name: | L-Glutamic acid alpha-amide | | Synonyms: | L-ISOGLUTAMINE HYDROCHLORIDE;L-ISOGLUTAMINE;H-GLU-NH2 HCL;H-ISOGLN-OH;L-GLUTAMIC ACID ALPHA-AMIDE;L-GLUTAMIC ACID ALPHA-AMIDE HYDROCHLORIDE;L-GLUTAMIC ACID AMIDE;GLUTAMIC ACID-NH2 | | CAS: | 636-65-7 | | MF: | C5H10N2O3 | | MW: | 146.14 | | EINECS: | | | Product Categories: | | | Mol File: | 636-65-7.mol |  |
| | L-Glutamic acid alpha-amide Chemical Properties |
| Melting point | 160 °C | | Boiling point | 423.1±40.0 °C(Predicted) | | alpha | D21 +20.5° (c = 6.1 in H2O) | | density | 1.321±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Water (Sparingly) | | form | Solid | | pka | pK1 3.81; pK2 7.88(at 25℃) | | color | White to Off-White | | Optical Rotation | 20.1°(C=0.50g/100ml H2O) |
| | L-Glutamic acid alpha-amide Usage And Synthesis |
| Preparation | N-CBZ-γ-benzyl-L-isoglutamine (5 gm.) was dissolved in 100 ml. of 50% ethanol and hydrogenated for 12 hr. at room temperature and atmospheric pressure in the presence of palladium catalyst (5% Pd on calcium carbonate). The catalyst was filtered off and a trace of calcium ions was removed with oxalic acid. The solution was evaporated to dryness, the residue dissolved in a small amount of hot water, and the solution treated with charcoal. Alcohol was added to the cloud point and L-isoglutamine was recovered from the chilled solution as fine white crystals, m.p. 186-188°, yield 65%. | | Chemical Properties | White to off-white powder | | Definition | ChEBI: L-isoglutamine is an isoglutamine that has L-configuration. It is an isoglutamine and a L-glutamic acid derivative. It is an enantiomer of a D-isoglutamine. |
| | L-Glutamic acid alpha-amide Preparation Products And Raw materials |
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