Boc-aminoxy-PEG4-acid manufacturers
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| | Boc-aminoxy-PEG4-acid Basic information |
| Product Name: | Boc-aminoxy-PEG4-acid | | Synonyms: | Boc-aminoxy-PEG4-acid;t-Boc-Aminooxy-PEG4-acid;N-Boc-Aminooxy-PEG4-acid;3,6,9,12,15-Pentaoxa-2-azaoctadecanedioic acid, 1-(1,1-dimethylethyl) ester;3-[2-[2-[2-[2-(tert-butoxycarbonylamino)oxyethoxy]ethoxy]ethoxy]ethoxy]propanoic acid;Boc-aminoxy-PEG4-acid boc-;BocHNO-PEG4-CH2CH2COOH | | CAS: | 2062663-68-5 | | MF: | C16H31NO9 | | MW: | 381.42 | | EINECS: | | | Product Categories: | | | Mol File: | 2062663-68-5.mol |  |
| | Boc-aminoxy-PEG4-acid Chemical Properties |
| density | 1.150±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 4.28±0.10(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | Boc-aminoxy-PEG4-acid Usage And Synthesis |
| Description | t-Boc-Aminooxy-PEG4-acid contains a Boc-protected aminooxy group and a terminal carboxylic acid. The terminal carboxylic acid (CO2H) is reactive with primary amine groups in the presence of EDC, to form a amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc-protected amine can be deprotected under mild acidic conditions. | | Uses | Boc-aminoxy-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Boc-aminoxy-PEG4-acid Preparation Products And Raw materials |
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