Boc-Aminooxy-PEG5-amine manufacturers
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| | Boc-Aminooxy-PEG5-amine Basic information |
| Product Name: | Boc-Aminooxy-PEG5-amine | | Synonyms: | Boc-Aminooxy-PEG5-amine;3,6,9,12,15,18-Hexaoxa-2-azaeicosanoic acid, 20-amino-, 1,1-dimethylethyl ester;t-Boc-Aminooxy-PEG5-amine boc;BocHNO-PEG5-CH2CH2NH2;Boc-HNO-PEG5-CH2CH2NH5;1,1-Dimethylethyl 20-amino-3,6,9,12,15,18-hexaoxa-2-azaeicosanoate | | CAS: | 2250216-94-3 | | MF: | C17H36N2O8 | | MW: | 396.48 | | EINECS: | | | Product Categories: | | | Mol File: | 2250216-94-3.mol |  |
| | Boc-Aminooxy-PEG5-amine Chemical Properties |
| density | 1.091±0.06 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 8.74±0.10(Predicted) |
| | Boc-Aminooxy-PEG5-amine Usage And Synthesis |
| Description | t-Boc-Aminooxy-PEG5-amine compound contains a Boc-protected aminooxy group and an amino group. The amino group is reactive with carboxylic acids, activated NHS esters. The protected aminooxy can be deprotected under mild acidic conditions and then can react with an aldehyde or ketone group to form a stable oxime linkage. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | Boc-Aminooxy-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651 |
| | Boc-Aminooxy-PEG5-amine Preparation Products And Raw materials |
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