5-FLUORO-2-NITROBENZONITRILE manufacturers
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| | 5-FLUORO-2-NITROBENZONITRILE Basic information |
| | 5-FLUORO-2-NITROBENZONITRILE Chemical Properties |
| Melting point | 84-88°C | | Boiling point | 302.9±27.0 °C(Predicted) | | density | 1.41±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | Powder | | Appearance | White to yellow Solid | | CAS DataBase Reference | 50594-78-0(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 20/21/22 | | Safety Statements | 26-36/37/39 | | RIDADR | 3439 | | Hazard Note | Irritant/Keep Cold | | HazardClass | 6.1 | | PackingGroup | Ⅲ | | HS Code | 2926907090 |
| | 5-FLUORO-2-NITROBENZONITRILE Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2-nitro-5-fluorobenzonitrile from 5-fluoro-2-nitrobenzamide was as follows: dry DMF (70 mL) was cooled to -10 °C and thionyl chloride (6 mL, 82 mmol) was added slowly and dropwise over 10 min. Subsequently, 5-fluoro-2-nitrobenzoic acid (15.04 g, 82 mmol) was added in batches over 1 hour. After the reaction mixture was gradually warmed to room temperature, it was poured into water (200 mL). The precipitate formed was collected by filtration, washed with water and dried to afford the target product 2-nitro-5-fluorobenzonitrile as a colorless solid (10.7 g, 79% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 8.41 (1H, m), 7.62 (1H, m), 7.52 (1H, m). | | References | [1] Patent: WO2006/129120, 2006, A2. Location in patent: Page/Page column 78
[2] Patent: US2010/280268, 2010, A1. Location in patent: Page/Page column 46 |
| | 5-FLUORO-2-NITROBENZONITRILE Preparation Products And Raw materials |
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