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| | 2-Amino-5-fluorobenzonitrile Basic information | | Uses |
| | 2-Amino-5-fluorobenzonitrile Chemical Properties |
| Melting point | 92-96 °C (lit.) | | Boiling point | 138 °C/15 mmHg (lit.) | | density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | powder | | pka | 1.87±0.10(Predicted) | | color | Faint yellow to faint brown | | InChI | 1S/C7H5FN2/c8-6-1-2-7(10)5(3-6)4-9/h1-3H,10H2 | | InChIKey | VFQDFQDXMNVDPW-UHFFFAOYSA-N | | SMILES | Nc1ccc(F)cc1C#N | | CAS DataBase Reference | 61272-77-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 20/21/22 | | Safety Statements | 22-24/25 | | RIDADR | 3439 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 2926907090 | | Storage Class | 11 - Combustible Solids |
| | 2-Amino-5-fluorobenzonitrile Usage And Synthesis |
| Uses | 2-Amino-5-fluorobenzonitrile is a key intermediate. | | Chemical Properties | white to light yellow crystal powder | | Synthesis | GENERAL METHODS: Azide-based compounds (1 mmol) were added to an aqueous solution (5 mL) containing freshly prepared Fe(0) nanoparticles (3 mmol) at room temperature and under argon atmosphere. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was extracted with ethyl acetate (3 × 10 mL), ensuring that all Fe-containing material was retained around the stir bar. Subsequently, the solvent in the organic phase was evaporated and the crude product was purified by short column chromatography. The final product was structurally confirmed by infrared spectroscopy (IR), proton nuclear magnetic resonance (1H NMR) and carbon nuclear magnetic resonance (13C NMR) data. | | References | [1] Tetrahedron Letters, 2017, vol. 58, # 35, p. 3457 - 3460 |
| | 2-Amino-5-fluorobenzonitrile Preparation Products And Raw materials |
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