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| | Betaxolol hydrochloride Basic information |
| Product Name: | Betaxolol hydrochloride | | Synonyms: | 1-[4-[2-(CYCLOPROPYLMETHOXY)ETHYL]PHENOXY]-3-ISOPROPYLAMINO-2-PROPANOL HYDROCHLORIDE;BETAXOLOL CHLOROHYDRATE;BETAXOLOL HYDROCHLORIDE;BETAXOLOL HYDROCHLORIDE MONOHYDRATE;(+-)-1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)-2-propano;1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-isopropylaminopropan-2-olhydroc;Betaxolol for peak identification;BETAXALOL HYDROCHLORIDE | | CAS: | 63659-19-8 | | MF: | C18H30ClNO3 | | MW: | 343.89 | | EINECS: | 264-384-3 | | Product Categories: | Cardiovascular;Adrenoceptor | | Mol File: | 63659-19-8.mol |  |
| | Betaxolol hydrochloride Chemical Properties |
| Melting point | 116° | | storage temp. | 2-8°C | | solubility | H2O: 36 mg/mL, soluble | | form | solid | | color | white | | Water Solubility | Soluble to 50 mM in water | | Merck | 14,1182 | | Stability: | Hygroscopic | | Major Application | pharmaceutical (small molecule) | | InChI | InChI=1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H | | InChIKey | CHDPSNLJFOQTRK-UHFFFAOYSA-N | | SMILES | C1(OCC(O)CNC(C)C)C=CC(CCOCC2CC2)=CC=1.Cl | | CAS DataBase Reference | 63659-19-8(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | RTECS | UA9823000 | | HS Code | 2922504500 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral | | Toxicity | LD50 in mice (mg/kg): 944 orally; 37 i.v. (Manoury) |
| | Betaxolol hydrochloride Usage And Synthesis |
| Description | Betaxolol (hydrochloride) (Item No. 26285) is an analytical reference standard categorized as a β1-adrenergic receptor antagonist. Formulations containing β-adrenergic receptor antagonists have been used to enhance physical performance in athletes. This product is intended for use in analytical forensic applications. This product is also available as a general research tool . | | Description | Betaxolol hydrochloride is a cardioselective β-adrenergic blocker, reportedly devoid
of intrinsic sympathomimetic and membrane stabilizing properties. Its long
duration of action permits once-daily dosing in mild to moderate hypertension. It
is also being evaluated in glaucoma. | | Chemical Properties | White or almost white, crystalline powder. | | Originator | Synthelabo (France) | | Uses | antifungal | | Uses | Betaxolol Hydrochloride, a cardioselective β1-adrenergic blocker. An antihypertensive; antiglaucoma. | | Definition | ChEBI: The hydrochloride salt of betaxolol. | | Brand name | Betoptic (Alcon); Kerlone (Sanofi Aventis). | | Biological Activity | Selective β 1 -adrenoceptor antagonist. | | storage | Store at RT | | References | [1] SEUNG-WOON MYUNG Cheon H J. Gas chromatograph–mass spectrometric method for the determination of carvedilol and its metabolites in human urine[J]. Journal of Chromatography B, 2005, 822 1: Pages 70-77. DOI: 10.1016/j.jchromb.2005.05.023
[2] PANKAJ GUPTA R G. Amino Functionalized Graphene Oxide and Polymer Nanocomposite Based Electrochemical Platform for Sensitive Assay of Anti-Doping Drug Atenolol in Biological Fluids[J]. Journal of The Electrochemical Society, 2016, 163 1. DOI: 10.1149/2.0281613jes
[3] A WELLSTEIN G G B D Palm. Affinity and selectivity of beta-adrenoceptor antagonists in vitro.[J]. Journal of Cardiovascular Pharmacology, 1986, 8 Suppl 11: S36-40. DOI: 10.1097/00005344-198511001-00006
[4] DOROTA POZAROWSKA Zbigniew D Piotr Pozarowski. Cytometric assessment of cytostatic and cytotoxic effects of topical glaucoma medications on human epithelial corneal line cells[J]. Cytometry Part B: Clinical Cytometry, 2009, 78B 2: 130-137. DOI: 10.1002/cyto.b.20493
[5] N. SHARIF. Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes.[J]. Journal of Ocular Pharmacology and Therapeutics, 2001, 26 1: 305-317. DOI: 10.1089/108076801753162726
[6] GLYN CHIDLOW Neville N O José Melena. Betaxolol, a β1-adrenoceptor antagonist, reduces Na+ influx into cortical synaptosomes by direct interaction with Na+ channels: comparison with other β-adrenoceptor antagonists[J]. British Journal of Pharmacology, 2009, 130 4: 759-766. DOI: 10.1038/sj.bjp.0703369 |
| | Betaxolol hydrochloride Preparation Products And Raw materials |
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