| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
- Kobe0065
-
- $39.00
-
2026-07-27
- CAS:436133-68-5
- Purity: 99.70%
- Supply Ability: 10g
- Kobe-0065
-
-
2026-06-30
- CAS:436133-68-5
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 20Tons
- Kobe-0065
-
- $1.00
-
2019-12-23
- CAS:436133-68-5
- Min. Order: 100g
- Purity: 99%
|
| | Kobe-0065 Basic information |
| | Kobe-0065 Chemical Properties |
| Melting point | >166°C (dec.) | | Boiling point | 485.1±55.0 °C(Predicted) | | density | 1.653±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | DMSO: soluble15mg/mL, clear | | pka | 9.25±0.70(Predicted) | | form | powder | | color | white to beige | | InChI | InChI=1S/C15H11ClF3N5O4S/c1-7-2-3-9(6-10(7)16)20-14(29)22-21-13-11(23(25)26)4-8(15(17,18)19)5-12(13)24(27)28/h2-6,21H,1H3,(H2,20,22,29) | | InChIKey | KSJVAYBCXSURMQ-UHFFFAOYSA-N | | SMILES | N(C(NC1=CC=C(C)C(Cl)=C1)=S)NC1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C1[N+]([O-])=O |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | Kobe-0065 Usage And Synthesis |
| Uses | N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-hydrazinecarbothioamide is used in the preparation of pyrazolidine or pyrazole compounds which exhibit mild antimicrobial effects against various strains of bacteria. | | Biological Activity | kobe0065 is a small-molecule inhibitor of ras with ki value of 46 μm for the binding of h-ras.gtp to c-raf-1 [1].kobe0065 is a compound screened out by an in silico screen method as a potent inhibitor of the ras–raf interaction. it showed favorite efficacy to inhibit the binding of m-ras.gtp and h-ras.gtp to the ras-binding domain of c-raf-1. kobe0065 also dose-dependently inhibited the binding of h-rasg12v to c-raf-1 in nih 3t3 cells with a rough ic50 value of 10 μm. besides that, 20 μm of kobe0065 effectively suppressed the phosphorylation of down-stream kinases of raf, including mek and erk. in nih 3t3 cells transfected with h-rasg12v, kobe0065 inhibited the colony formation with ic50 value of 0.5 μm. kobe0065 also showed effect on other cancer cells carrying activated ras oncogenes, such as panc-1(k-rasg12v), ht1080 (n-rasq61l) and hct116 (h-rasg13d). moreover, in mice bearing sw480 xenografts, administration of kobe0065 resulted in 40-50% inhibition of the tumor growth at dose of 80 mg/kg. this effect turned to be more distinct when the dose was up to 160 mg/kg [1]. | | in vivo | Kobe0065 and Kobe2602 exhibit antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-ras(G12V) gene by oral administration[1]. | | IC 50 | H-Ras | | references | [1] shima f, yoshikawa y, ye m, et al. in silico discovery of small-molecule ras inhibitors that display antitumor activity by blocking the ras–effector interaction. proceedings of the national academy of sciences, 2013, 110(20): 8182-8187. |
| | Kobe-0065 Preparation Products And Raw materials |
|