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4,4'-Dipyridyl disulfide

4,4'-Dipyridyl disulfide Suppliers list
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4,4'-Dipyridyl disulfide manufacturers

4,4'-Dipyridyl disulfide Basic information
Product Name:4,4'-Dipyridyl disulfide
Synonyms:4-(4-Pyridinyldisulfanyl)pyridine;4,4'-Dipyridine disulfide;4,4'-Dithiopyridine;4-Pyridyl disulfide;Aldrithiol 4;Aldrithol-4;Bis(4-pyridyl) disulfide;Di(4-pyridyl) disulfide
CAS:2645-22-9
MF:C10H8N2S2
MW:220.31
EINECS:220-158-6
Product Categories:Condensation & Active Esterification;Synthetic Organic Chemistry;Pyridine series
Mol File:2645-22-9.mol
4,4'-Dipyridyl disulfide Structure
4,4'-Dipyridyl disulfide Chemical Properties
Melting point 76-78 °C(lit.)
Boiling point 356.1±17.0 °C(Predicted)
density 1.3078 (rough estimate)
refractive index 1.5500 (estimate)
storage temp. 2-8°C
solubility 95% ethanol: soluble5%, clear, colorless to light yellow
form Crystalline Powder
pka3.60±0.26(Predicted)
color White to orange
BRN 154742
InChIInChI=1S/C10H8N2S2/c1-5-11-6-2-9(1)13-14-10-3-7-12-8-4-10/h1-8H
InChIKeyUHBAPGWWRFVTFS-UHFFFAOYSA-N
SMILESS(C1C=CN=CC=1)SC1C=CN=CC=1
CAS DataBase Reference2645-22-9(CAS DataBase Reference)
NIST Chemistry ReferencePyridine, 4,4'-dithiobis-(2645-22-9)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-24/25
WGK Germany 3
HS Code 29333990
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
4,4'-Dipyridyl disulfide Usage And Synthesis
Chemical Propertieswhite to orange crystalline powder
Uses
  • Aldrithiol-4 was used as cosubstrate in a study to develop highly specific inhibitors against mannose-binding lectin-associated serine proteases by in vitro evolution technology:phage display.
  • It was used to study the O2 equilibria of recombinant human neuroglobin and cytoglobin measured under close to physiological conditions.
  • It was used to modify gold surfaces for protein studies.
DefinitionChEBI: An organic disulfide obtained by formal oxidative dimerisation of 4-thiopyridine.
Purification MethodsRecrystallise the disulfide from H2O, EtOH, Me2CO, *C6H6 or pet ether. It has been used as a 1mM solution in EtOH for the spectrophotometric estimation of thiols. Essentially the thiol displaces half the disulfide molecule liberating the 4-mercaptopyridine (4-pyridinethiol) anion, thereby shifting the max from 324nm (of the disulfide) to 285nm (of the anion) at pH 9. (Compare with 2,2’dipyridyl disulfide above which has been used for the same purpose.) [Humphrey et al. Anal Chem 40 698 1970, Cheng & Ritchie Aust J Chem 26 1785 1973.] [Beilstein 21 II 35, for review see Aldrichimica Acta 4 33 1971.]
4,4'-Dipyridyl disulfide Preparation Products And Raw materials
Preparation Products4,4'-Dipyridyl sulfide
Tag:4,4'-Dipyridyl disulfide(2645-22-9) Related Product Information
S-Methyl methanethiolsulfonate 4,4'-Bipyridine 4,4'-Dipyridyl disulfide Dimethyl disulfide 4-Mercaptopyridine 2,2'-Dithiodipyridine 3,3'-dipyridyl disulfide