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| | Mal-Amido-PEG4-t-butyl ester Basic information |
| Product Name: | Mal-Amido-PEG4-t-butyl ester | | Synonyms: | Mal-Amido-PEG4-t-butyl ester;MAL-NH-PEG4-CH2CH2COOTBU;Mal-NH-PEG4-OtBu;Mal-Amido-PEG4-Boc;4,7,10,13-Tetraoxa-16-azanonadecanoic acid, 19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-17-oxo-, 1,1-dimethylethyl ester;Maleimide-C2-Amido-PEG4-Carboxylic Acid tert-Butyl Ester;N-(18,18-Dimethyl-15-oxo-3,6,9,12,17-pentaoxanonadec-1-yl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide;tert-butyl 3-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate | | CAS: | 1415800-35-9 | | MF: | C22H36N2O9 | | MW: | 472.53 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1415800-35-9.mol |  |
| | Mal-Amido-PEG4-t-butyl ester Chemical Properties |
| solubility | DMSO : 200 mg/mL (423.25 mM; Need ultrasonic) | | form | clear liquid | | color | Colorless to Light yellow |
| | Mal-Amido-PEG4-t-butyl ester Usage And Synthesis |
| Description | Mal-Amido-PEG4-t-butyl ester is a PEG linker containing a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | | Uses | Mal-Amido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Mal-Amido-PEG4-t-butyl ester Preparation Products And Raw materials |
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