| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
1-Acetoxy-3-fluorobenzene manufacturers
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| | 1-Acetoxy-3-fluorobenzene Basic information |
| | 1-Acetoxy-3-fluorobenzene Chemical Properties |
| Boiling point | 77-78 °C13 mm Hg(lit.) | | density | 1.147 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.4800(lit.) | | Fp | 168 °F | | storage temp. | Sealed in dry,Room Temperature | | form | clear liquid | | color | Colorless to Almost colorless | | BRN | 2555261 | | InChI | 1S/C8H7FO2/c1-6(10)11-8-4-2-3-7(9)5-8/h2-5H,1H3 | | InChIKey | IAWZWMGUTKRLQB-UHFFFAOYSA-N | | SMILES | CC(=O)Oc1cccc(F)c1 | | CAS DataBase Reference | 701-83-7(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38-43 | | Safety Statements | 26-24/25 | | RIDADR | 2810 | | WGK Germany | 3 | | Hazard Note | Harmful | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29153900 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 |
| | 1-Acetoxy-3-fluorobenzene Usage And Synthesis |
| Chemical Properties | colourlesstolightyellowliqui | | Synthesis | 3-Fluorophenol (10 g, 89 mmol) was dissolved in acetic anhydride (90 mmol). Concentrated sulfuric acid (3 drops) was added as a catalyst and the reaction mixture was heated to 120°C. After completion of the reaction, the mixture was slowly poured into ice water (100 ml) containing NaHCO3 (1 g) to neutralize the acid. Subsequently, the organic phase was separated by extraction with ethyl acetate. The organic phase was washed sequentially with saturated NaHCO3 solution to remove residual acid and dried with anhydrous Na2SO4. Finally, the solvent was removed by distillation under reduced pressure to give 3-fluorophenol acetate (10.5 g), and the product was used directly in the subsequent reaction. | | References | [1] Chemistry - A European Journal, 2015, vol. 21, # 5, p. 2241 - 2249
[2] Journal of Medicinal Chemistry, 1987, vol. 30, # 5, p. 814 - 820
[3] Journal of Medicinal Chemistry, 2018, vol. 61, # 7, p. 3037 - 3058
[4] Patent: CN105085427, 2018, B. Location in patent: Paragraph 0331; 0333; 0335; 0336 |
| | 1-Acetoxy-3-fluorobenzene Preparation Products And Raw materials |
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