- 4-Benzyloxybenzaldehyde
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- $0.00 / 1g
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2026-02-02
- CAS:4397-53-9
- Min. Order: 10mg
- Purity: 99%HPLC
- Supply Ability: 2000tons
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| | 4-Benzyloxybenzaldehyde Basic information |
| | 4-Benzyloxybenzaldehyde Chemical Properties |
| Melting point | 71-74 °C (lit.) | | Boiling point | 197-199 °C (11 mmHg) | | density | 1.1035 (rough estimate) | | refractive index | 1.6000 (estimate) | | Fp | 197-199°C/20mm | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Ethyl Acetate (Sparingly) | | form | Crystalline Powder | | color | Creamish to yellow | | Water Solubility | insoluble | | Sensitive | Air Sensitive | | BRN | 1242385 | | InChI | 1S/C14H12O2/c15-10-12-6-8-14(9-7-12)16-11-13-4-2-1-3-5-13/h1-10H,11H2 | | InChIKey | ZVTWZSXLLMNMQC-UHFFFAOYSA-N | | SMILES | [H]C(=O)c1ccc(OCc2ccccc2)cc1 | | LogP | 3.360 (est) | | CAS DataBase Reference | 4397-53-9(CAS DataBase Reference) | | NIST Chemistry Reference | Benzyl 4-formylphenyl ether(4397-53-9) | | EPA Substance Registry System | Benzaldehyde, 4-(phenylmethoxy)- (4397-53-9) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | F | 9-23 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 29124900 | | Storage Class | 11 - Combustible Solids |
| | 4-Benzyloxybenzaldehyde Usage And Synthesis |
| Chemical Properties | creamish to yellow crystalline powder | | Uses | 4-Benzyloxybenzaldehyde is a position isomer of the adenylyl cyclase activator 2-Benzyloxybenzaldehyde. 4-Benzyloxybenzaldehyde also has much less potent anticancer activity against HL-60 cells that i
ts isomeric counterpart. | | Uses | 4-Benzyloxybenzaldehyde is used in the synthesis of (5-fluoro-(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanenitrile),an estrogen receptor β-selective ligand. It is a position isomer of the adenylyl cyclase activator 2-benzyloxybenzaldehyde. | | Synthesis Reference(s) | Journal of Medicinal Chemistry, 32, p. 192, 1989 DOI: 10.1021/jm00121a035 | | General Description | 4-(Benzyloxy)benzaldehyde was used in the synthesis of (5-fluoro-(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanenitrile),an estrogen receptor β-selective ligand. | | Synthesis | P-hydroxybenzaldehyde 5g (41mmol) and potassium carbonate 11.3g into a three-necked flask, add N, N-dimethylformamide (DMF) 25ml, stirring for 15min to form a suspension, dropwise addition of benzyl chloride 5.7g (45mmol), the reaction at room temperature of 6-8h, TLC tracking reaction to the end of the ice-water mixture was poured into a large number of solids precipitation, filtration, washed a number of times with water. Filtered, washed with water for several times, dried to obtain a white solid 4-benzyloxybenzaldehyde 8.13g (yield 94%). |
| | 4-Benzyloxybenzaldehyde Preparation Products And Raw materials |
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