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| Product Name: | CARCINOEMBRYONIC ANTIGEN | | Synonyms: | Monoclonal Anti-CEACAM5 antibody produced in mouse;ANTI-PSG2 (C-TERM) antibody produced in rabbit;ANTI-CEA (CENTER) antibody produced in rabbit;Anti-CEACAM5 antibody produced in rabbit;Mouse Anti-Human CEA antibody;Mouse Anti-CEA antibody;CD66e;Carcinoembryonic Antigen (CEA) ELISA Kit | | CAS: | | | MF: | 0 | | MW: | 0 | | EINECS: | | | Product Categories: | proteins | | Mol File: | Mol File |  |
| | CARCINOEMBRYONIC ANTIGEN Chemical Properties |
| storage temp. | −20°C | | solubility | aqueous buffer: soluble | | form | buffered aqueous solution | | biological source | rabbit |
| Hazard Codes | Xn,B | | Risk Statements | 20/21/22-21/22 | | Safety Statements | 36/37 | | WGK Germany | - | | HS Code | 3504009000 | | Storage Class | 10 - Combustible liquids |
| | CARCINOEMBRYONIC ANTIGEN Usage And Synthesis |
| Uses | Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:1000-1:10000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. | | Uses | Carcinoembryonic Antigen human has been used as a standard in electrochemical immunosensor and developed surface plasmon resonance imaging (SPRi) immunosensor. It has also been used as a tumor-associated antigen (TAA) in enzyme-linked immunosorbent assay | | Uses | Suggested starting dilutions are as follows: IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. | | General Description | Carcinoembryonic antigen(CEA) or CEA cell adhesion molecule 5 (CEACAM5), is encoded by the gene mapped to human chromosome 19q13.2. CEACAM5 is a member of the CEACAM family. This glycosylated protein contains a typical N-terminal variable immunoglobulin (Ig)-like domain, constant Ig-like domain, and a hydrophobic transmembrane domain with a glycosylphosphatidylinositol lipid moiety. | | Biochem/physiol Actions | Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).[supplied by OMIM] | | Description | CEA Human Recombinant is glycosylated with N-linked sugars and produced using baculovirus vectors in insect cells. CEA is a well-known tumor marker corresponding to the full length human CEA which is approximately 120,000 Dalton. | | Source | Baculovirus Insect Cells | | Background | Carcinoembryonic antigen (CEA) is a glycoprotein present in fetal digestive-tract tissues; it’s involved in cell adhesion. The production of CEA stops before birth. CEA is called tumor marker since its elevated levels are found in the serum from individuals with colorectal, gastric, pancreatic, lung and breast carcinomas and in heavy smokers.
There are also benign conditions that elevate CEA levels such as smoking, infection, inflammatory bowel disease, pancreatitis, cirrhosis of the liver, and some benign tumors (in the equivalent organs which have cancers with elevated CEA). Typically, higher levels of CEA are found in men, smokers, and older individuals.
The presence of CEA assists in screening, in evaluating recurrent or disseminated disease, and in determining the success of surgical removal of malignant tumors.
CEA levels can be used as indicators of treatment success. The normal values range from 0.0 to 2.5 ng/ml of serum (from blood), in non-smokers, a greater amount than that may be suggestive of cancer. Levels above 20 ng/ml before treatment are associated with cancer which has already metastasized. Benign conditions do not usually cause a CEA increase over 10 ng/ml.
The high levels of CEA should return to normal after successful therapy, however if during follow up there’s an elevation in CEA levels it indicates a recurrence of tumor.
Carcinoembryonic antigen family belongs to the immunoglobulin superfamily; it consists of 29 genes, 18 of which are normally expressed. |
| | CARCINOEMBRYONIC ANTIGEN Preparation Products And Raw materials |
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