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| | Methyl 2-aminothiazole-5-carboxylate Basic information |
| | Methyl 2-aminothiazole-5-carboxylate Chemical Properties |
| Melting point | 182-186°C | | Boiling point | 298.7±13.0 °C(Predicted) | | density | 1.408±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 3.02±0.10(Predicted) | | color | Tan to Light Brown | | InChI | InChI=1S/C5H6N2O2S/c1-9-4(8)3-2-7-5(6)10-3/h2H,1H3,(H2,6,7) | | InChIKey | UJNNCGWBDJHCEM-UHFFFAOYSA-N | | SMILES | S1C(C(OC)=O)=CN=C1N | | CAS DataBase Reference | 6633-61-0(CAS DataBase Reference) |
| | Methyl 2-aminothiazole-5-carboxylate Usage And Synthesis |
| Uses | Methyl 2-Aminothiazole-5-carboxylate (cas# 6633-61-0) is a compound useful in organic synthesis. | | Synthesis | General procedure for the synthesis of methyl 2-aminothiazole-5-carboxylate from methyl 2-chloro-3-oxopropionate and compound (CAS:17356-08-0): a mixture of 2.4 g of methyl 2-chloro-3-oxopropionate, 20 mL of water, and 1.75 g of thiourea was refluxed for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature, decolorized by adding 0.25 g of activated carbon (Norit) and filtered. The filtrate was adjusted to neutral pH by slowly adding 2.5 N sodium hydroxide solution to the filtrate.The precipitate was collected by filtration to give 1.23 g (44% yield) of methyl 2-aminothiazole-5-carboxylate. | | References | [1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991, # 3, p. 349 - 352
[2] Patent: WO2003/97616, 2003, A1. Location in patent: Page/Page column 26
[3] Journal of the American Chemical Society, 1952, vol. 74, p. 5799
[4] Ann. Rep. Res. Inst. Tuberc. Kanazawa Univ., 1953, vol. 11, # 2, p. 39,41
[5] Chem.Abstr., 1955, p. 8250 |
| | Methyl 2-aminothiazole-5-carboxylate Preparation Products And Raw materials |
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